DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9135 and SERGEF

DIOPT Version :9

Sequence 1:NP_001285655.1 Gene:CG9135 / 33850 FlyBaseID:FBgn0031769 Length:487 Species:Drosophila melanogaster
Sequence 2:NP_036271.1 Gene:SERGEF / 26297 HGNCID:17499 Length:458 Species:Homo sapiens


Alignment Length:404 Identity:94/404 - (23%)
Similarity:153/404 - (37%) Gaps:122/404 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 SGPSAAHTILINMDRKALGFGRNPSGQLGLSQDIKLAEKPTIIPALEQLN-------IVQAAVGR 178
            :.|:||         ....:|.|..|||||..     ::..::|  :|||       :.:...|.
Human    10 AAPAAA---------ALFAWGANSYGQLGLGH-----KEDVLLP--QQLNDFCKPRSVRRITGGG 58

  Fly   179 HHTLFLTDTGTVYACGENKSGQCGVGNTHANIYSPTPINYRGPPIIRIGCGAEFSVILDIKGSLH 243
            .|:..:||.|.::.||.||.||.|:|:|....|.....:..|.||.::.||.:|:::|...|.:.
Human    59 GHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVL 123

  Fly   244 TFGLPEYGQLG--HNTDAKYFVNANKLSFHFETSPKKVVL--YIEKSKEGHVTPVDGVQIVDFAC 304
            :.|...:||||  |                   .|::.|:  .||..||         ::|..|.
Human   124 SCGSNSFGQLGVPH-------------------GPRRCVVPQAIELHKE---------KVVCIAA 160

  Fly   305 GNNHTVAIDSKKRVYSWGFG--GFGRLGHAEPKDEMVP-RLMKFFDTQGRGGR----------SV 356
            |..|.||..:...|:.||.|  ..||        .:.| :.:..|.|.....|          .|
Human   161 GLRHAVAATASGIVFQWGTGLASCGR--------RLCPGQTLPLFFTAKEPSRVTGLENSKAMCV 217

  Fly   357 FCGSTFSLIVNELGLLFLFGQNKK---TGEANMYPKPVQDL--------------SGWNITDIGC 404
            ..||..|..:.:.|.::::|.||.   ..||...|.| |.:              |||       
Human   218 LAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVP-QKIEAHCFQNEKVTAIWSGW------- 274

  Fly   405 ANTSIMISADDT--LIAWGASPTFGELG-------------IGEFQKSSTVPKEVPKLDN--IKI 452
               :.:::..:|  :..||.: .:|:||             ...|...|..|..:|...:  ...
Human   275 ---THLVAQTETGKMFTWGRA-DYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGA 335

  Fly   453 PQVTMGYSHTVLLV 466
            .:|:.|..|.:.::
Human   336 TEVSCGSEHNLAII 349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9135NP_001285655.1 RCC1 139..184 CDD:278826 13/51 (25%)
RCC1_2 171..200 CDD:290274 9/28 (32%)
RCC1 188..236 CDD:278826 17/47 (36%)
RCC1 239..312 CDD:278826 18/76 (24%)
RCC1 317..366 CDD:278826 14/61 (23%)
RCC1 414..465 CDD:278826 13/67 (19%)
SERGEFNP_036271.1 RCC1 1 15..67 15/67 (22%)
RCC1 23..64 CDD:278826 12/47 (26%)
RCC1 2 68..119 18/50 (36%)
RCC1 68..116 CDD:278826 17/47 (36%)
RCC1_2 103..132 CDD:290274 7/28 (25%)
RCC1 119..167 CDD:278826 17/75 (23%)
RCC1 3 120..171 19/78 (24%)
RCC1 4 172..230 14/65 (22%)
RCC1_2 219..243 CDD:290274 7/23 (30%)
RCC1 5 231..283 12/62 (19%)
RCC1 231..279 CDD:278826 12/58 (21%)
RCC1 6 284..351 12/67 (18%)
RCC1 284..348 CDD:278826 12/64 (19%)
RCC1 351..399 CDD:278826
RCC1 7 352..402
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..458
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5530
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.850

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