DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9135 and IBTK

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_006715516.1	Gene:	IBTK / 25998	HGNCID:	17853	Length:	1394	Species:	Homo sapiens

Alignment Length:	380	Identity:	88/380 - (23%)
Similarity:	143/380 - (37%)	Gaps:	88/380 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 HTILINMDRKALGFGRNPSGQLGLSQDIKLAEKPTIIPALEQLNIVQAAVGRHHTLFLTDTGTVY 191
            |::.::...:....|..|.|:|| ..|.:....|.::..|...|..|.|..:.||:.||:.|.||
Human   188 HSVFLSQKGQVYTCGHGPGGRLG-HGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVY 251

  Fly   192 ACGENKSGQCGVGNTHANIYSPTPIN---YRGPPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQL 253
            ..|.|...|.|:....::...|..|.   .:|..||.:..| .|..:|..:.:::|.|| ..|||
Human   252 TFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG-RFHTVLWTREAVYTMGL-NGGQL 314

  Fly   254 GHNTDAKYFVNANKLSFHFETSP--------KKVVLYIEKSKEGHVTPV----DGVQIVDFACGN 306
            |...|.    |..|.    .|:|        |.:.|.:..:.:|....|    |...:.|:.|..
Human   315 GCLLDP----NGEKC----VTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKK 371

  Fly   307 NHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDTQGRGGRSVFCGSTFSLIVNELGL 371
            ..:..::.||.:.|.        ||.|.|.:  |..:|     ..||:.: |    .|.::..|.
Human   372 MASKQLNLKKVLVSG--------GHMEYKVD--PEHLK-----ENGGQKI-C----ILAMDGAGR 416

  Fly   372 LFLF-GQNKKTGEAN-MYPKPVQDLSGWNITDIGCANTSIMISADDTLIAWGASPTFGELGIG-- 432
            :|.: ..|....:.. .||:.|      .|:||......|:....|           ||...|
Human   417 VFCWRSVNSSLKQCRWAYPRQV------FISDIALNRNEILFVTQD-----------GEGFRGRW 464

  Fly   433 --EFQKSSTVPKEVPKLDN-----------------IKIPQVTMGYSHTVLLVDT 468
              |.:|||...:.:..|.|                 |::.::|  ::|..:.|.|
Human   465 FEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLT--FAHRAVSVST 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	13/44 (30%)
		RCC1_2	171..200	CDD:290274	11/28 (39%)
		RCC1	188..236	CDD:278826	14/50 (28%)
		RCC1	239..312	CDD:278826	19/84 (23%)
		RCC1	317..366	CDD:278826	11/48 (23%)
		RCC1	414..465	CDD:278826	13/71 (18%)
IBTK	XP_006715516.1	ANK	25..135	CDD:238125
		Ank_2	25..116	CDD:289560
		ANK repeat	51..82	CDD:293786
		ANK repeat	84..116	CDD:293786
		RCC1	143..192	CDD:278826	1/3 (33%)
		RCC1	195..244	CDD:278826	13/49 (27%)
		ATS1	227..>458	CDD:227511	65/277 (23%)
		RCC1	247..299	CDD:278826	14/52 (27%)
		BTB	554..>642	CDD:279045
		BTB	565..>639	CDD:197585
		BTB	761..867	CDD:279045
		BTB	769..867	CDD:197585
		SPOP_C_like	871..931	CDD:269810
		GVQW	1248..>1284	CDD:290611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900