DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and Herc1

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_006511166.1	Gene:	Herc1 / 235439	MGIID:	2384589	Length:	4885	Species:	Mus musculus

Alignment Length:	450	Identity:	125/450 - (27%)
Similarity:	193/450 - (42%)	Gaps:	92/450 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DLDPPSKLPEDLLATLEKTPGQMLIAGM------------VTWDLTGKRDRKNVTKVRPNLYSF- 108
            ||:|   :|||.|..|  ......|.||            ..|.|.||.|          :|.:
Mouse  3978 DLEP---VPEDELVLL--MDNSKWINGMDEQIMSWATSRPEDWHLGGKCD----------VYLWG 4027

  Fly   109 ---HRFTEEKYRYV---ASGPSAAH----------TILINMDRKALGFGRNPSGQLGL--SQDIK 155
               |....|..|.|   |:.||.:.          |.:|..:...|..|....|:||.  |.|:.
Mouse  4028 AGRHGQLAEAGRNVMVPATAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLH 4092

  Fly   156 LAEKPTIIPALEQLNIVQAAV---GRHHTLFLTDTGTVYACGENKSGQCGVGNTHANIYSPTPIN 217
            :.   |:|.||:...:.|...   ...|::.||::|.|::.|:...|:.|.||:... ..|..|.
Mouse  4093 VL---TVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQ-RRPRQIE 4153

  Fly   218 -YRGPPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVVL 281
             .:|..::::.||.:.|.::...|.|.|||..:||:||..                .||.||:
Mouse  4154 ALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLG----------------NTSNKKL-- 4200

  Fly   282 YIEKSKEGHVTPVDGVQIVDFACGNNHTVAIDSK-KRVYSWGFGGFGRLGHAEPKDEMVPRLMKF 345
                  ...||.::|.||...|||.|||:|:.:. ..|:::|.|.:|:||......:..|:  |.
Mouse  4201 ------PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQ--KV 4257

  Fly   346 FDTQGRGGRSVFCGSTFSLIVNELGLLFLFGQNK----KTGEANMYPKPVQ--DLSGWNITD--I 402
            ....|.|.:.|.||:.||:.:.:.|.::.|||::    ..|.|..:.:|.|  .|:|..|.|  :
Mouse  4258 DVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAV 4322

  Fly   403 GCANTSIMISADDTLIAWGASPTFGELGIGEFQKSSTVPKEVPKLDNIKIPQVTMGYSHT 462
            |..:|..:.|..| :.||| |.:.|:||:|. ......|..|..|....|.|::.|..|:
Mouse  4323 GAEHTLALASTGD-VYAWG-SNSEGQLGLGH-TNHVREPTLVTVLQGKNIRQISAGRCHS 4379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	12/49 (24%)
		RCC1_2	171..200	CDD:290274	7/31 (23%)
		RCC1	188..236	CDD:278826	13/48 (27%)
		RCC1	239..312	CDD:278826	24/72 (33%)
		RCC1	317..366	CDD:278826	15/48 (31%)
		RCC1	414..465	CDD:278826	16/48 (33%)
Herc1	XP_006511166.1	ATS1	374..731	CDD:227511
		SPRY_HERC1	2039..2196	CDD:293939
		UBA_HERC1	2760..2803	CDD:270584
		WD40	3448..3799	CDD:392136
		WD40 repeat	3456..3499	CDD:293791
		WD40 repeat	3513..3548	CDD:293791
		WD40 repeat	3610..3648	CDD:293791
		WD40 repeat	3653..3689	CDD:293791
		WD40 repeat	3697..3736	CDD:293791
		WD40 repeat	3774..3810	CDD:293791
		ATS1	4022..4370	CDD:227511	106/390 (27%)
		HECTc	4497..4865	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820