DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and Eea1

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_006513585.1	Gene:	Eea1 / 216238	MGIID:	2442192	Length:	1458	Species:	Mus musculus

Alignment Length:	163	Identity:	39/163 - (23%)
Similarity:	69/163 - (42%)	Gaps:	30/163 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KKKESDY---EDEFSDESDDDGVQQQAAAANQMEVLIPHDDLDPPSKLPEDLLA---TLEKTPGQ 78
            :||:.||   |::.::||         |:...::..:...||| ..:|...|.|   :|::..|:
Mouse   359 QKKDLDYTHLEEKHNEES---------ASRKTLQASLHQRDLD-CQQLQARLTASESSLQRAQGE 413

  Fly    79 MLIAGMVTWDLTGKRDRKNVTKVRPNL----YSFHRFTEEKYRY---VASGPSAAHTILINMDRK 136
            :.........|  :.:.:.|...|.:|    ....:..|||.::   :....|..|..|:..:|:
Mouse   414 LSEKAEAAQKL--REELREVESTRQHLKVEVKQLQQQREEKEQHGLQLQGEVSQLHCKLLETERQ 476

  Fly   137 ALG--FGRNPSGQLGLSQDIKLAEKPTIIPALE 167
             ||  .||... |..||.: ||.||...:..|:
Mouse   477 -LGEAHGRLKE-QRQLSSE-KLMEKEQQVADLQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	11/31 (35%)
		RCC1_2	171..200	CDD:290274
		RCC1	188..236	CDD:278826
		RCC1	239..312	CDD:278826
		RCC1	317..366	CDD:278826
		RCC1	414..465	CDD:278826
Eea1	XP_006513585.1	SMC_prok_B	<130..794	CDD:274008	39/163 (24%)
		Smc	504..1346	CDD:224117	1/3 (33%)
		FYVE_EEA1	1394..1456	CDD:277269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900