DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and ran-3

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_495753.1	Gene:	ran-3 / 174332	WormBaseID:	WBGene00004304	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	606	Identity:	130/606 - (21%)
Similarity:	207/606 - (34%)	Gaps:	222/606 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PNKRRPKKKESDYEDEFSDESDDDGVQQQAAAANQMEVLIPHDDLDP-----PSKLPEDLLATLE 73
            |...:|:...|...:...||...:.|:..|......:.::.:....|     |.|||....|..|
Worm    28 PRADQPESSASGARNHGEDEEVTEQVELAAMETEASDSIVDNVPKTPRRAGRPKKLPSTSTAAAE 92

  Fly    74 ---------------------------------KTPGQ---MLIAGMVTWDLTGKRDRKNVTKVR 102
                                             ||||:   .|:|.::|:||           ..
Worm    93 SAVTPGKRGRKRKGSESVNTTINSTMNSTLNEPKTPGRKQAKLVAPLLTYDL-----------FA 146

  Fly   103 PNLYSFHRFTEEKYRYVASGPSAAHTILINMDRKALGF-GRNPSGQLGLSQDIKLAEKPTIIPAL 166
            |::..        .|.::.|           :.:|||. ||..:            :||..:...
Worm   147 PSIIG--------DRVLSCG-----------EGEALGHPGRTTT------------KKPRKVDIF 180

  Fly   167 EQ--LNIVQAAVGRHHTLFLTDTGTVYACGENKSGQC---GV---GNT--HANIYSPTPINYRGP 221
            |:  |..:||..|..|:..||..|.||.||.|:.|..   ||   |:|  .|.:.....|...|
Worm   181 EEEGLKPLQAVAGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIEKEG- 244

  Fly   222 PIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVVLYIEKS 286
            .|:.:..||.|:..|..:||:..     :|.| .|::..  |:.:.|....:.:|   |:.:.::
Worm   245 KIVMLAAGASFTAALTDQGSVIA-----WGNL-RNSNGN--VDVHPLLHKMQEAP---VVIVHQA 298

  Fly   287 KEGHVTPVDGVQIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHA-------------EPKDEM 338
            |.         :||..|.|.||.|.:|.|..:.::|.|..|:||.:             |..|.:
Worm   299 KR---------KIVKIAAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHL 354

  Fly   339 VPRLM-----KFFDTQGRGGRSVFCGSTFSLIVNELGLLFLFGQNK------KTGEANMYPKPVQ 392
            :..|.     ||||..   .::||....::::..|.|..:.||.|.      |..||:: .:..|
Worm   355 LVPLRFKHKGKFFDVV---AKNVFASGFWTIVHGEDGKYYAFGLNNYAQLGIKVDEADV-GQDGQ 415

  Fly   393 D---------------------------------------------------LSGWNITD----- 401
            |                                                   |..|...|
Worm   416 DNRELRVFLPAEAPAFGAERTFVNIEGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHW 480

  Fly   402 --------------IGCA---NTSIMISADDTLIAWGASPTFGELGIG---EFQKSSTVPKEVPK 446
                          :|.:   .|||..|.|.|..|||...| |:||:|   |.:|..:.|:|:..
Worm   481 LYDTIQEIEFDSKIVGVSAKLATSIAWSEDGTAYAWGFDTT-GQLGLGLKDEDEKMVSKPEEISS 544

  Fly   447 --LDNIKIPQVTMGYSHTVLL 465
              ||...|...::...||:::
Worm   545 AHLDGYSIIGASISDQHTLII 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	11/47 (23%)
		RCC1_2	171..200	CDD:290274	12/28 (43%)
		RCC1	188..236	CDD:278826	18/55 (33%)
		RCC1	239..312	CDD:278826	17/72 (24%)
		RCC1	317..366	CDD:278826	14/66 (21%)
		RCC1	414..465	CDD:278826	19/55 (35%)
ran-3	NP_495753.1	ATS1	163..569	CDD:227511	103/441 (23%)
		RCC1_2	189..215	CDD:290274	12/25 (48%)
		RCC1_2	246..276	CDD:290274	10/35 (29%)
		RCC1_2	302..331	CDD:290274	11/28 (39%)
		RCC1	510..565	CDD:278826	19/55 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910