DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and RCC1

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001041659.1	Gene:	RCC1 / 1104	HGNCID:	1913	Length:	452	Species:	Homo sapiens

Alignment Length:	499	Identity:	126/499 - (25%)
Similarity:	196/499 - (39%)	Gaps:	86/499 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKRKAGGNGAGPNKRR-------PKKKESDYEDEFSDESDDDGVQQQAAAANQMEVLIPHD-- 56
            ||.||.|        |||       ||.|:               |:...|||::.   :|..
Human     1 MSPKRIA--------KRRSPPADAIPKSKK---------------VKDTRAAASRR---VPGARS 39

  Fly    57 -----DLDPPSKLPEDLLATLEKT-PGQMLIAGMVTWDLTGKRDRKNV-TKVRPNLYSFHRFTEE 114
                 ...||.:....:......| ||.:|..|.......|..:  || .:.:|.|.|   ..|:
Human    40 CQGACGPSPPDQKTRPVSHRSHSTEPGLVLTLGQGDVGQLGLGE--NVMERKKPALVS---IPED 99

  Fly   115 KYRYVASGPSAAHTILINMDRKALGFGRNPSGQLGLSQDIKLAEKPTIIPALEQL--NIVQAAVG 177
            ..:..|.|   .||:.::...:...||.|..|.||....::.:|   ::|...:|  .:||.:.|
Human   100 VVQAEAGG---MHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE---MVPGKVELQEKVVQVSAG 158

  Fly   178 RHHTLFLTDTGTVYACGENKSGQCGVGNTHANIYSPTPINYR-GPPIIRIGCGAEFSVILDIKGS 241
            ..||..|||.|.|:..|..:.....:|.......|..|:..: ..|::::..|.:..|:|...|.
Human   159 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGD 223

  Fly   242 LHTFGLPEYGQLGHNTDAKYFVN-ANKLSFHFETSPKKVVLYIEKSKEGHVTPVDGVQIVDFACG 305
            |:|.|..|.||||...:  .|.| ..:........||.|:|. .:...||      |:..|..||
Human   224 LYTLGCGEQGQLGRVPE--LFANRGGRQGLERLLVPKCVMLK-SRGSRGH------VRFQDAFCG 279

  Fly   306 NNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDTQGR-------GGRSVFC----G 359
            ...|.||..:..||.:|...:.:||....:...:|:.:..|....:       |.....|    |
Human   280 AYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEG 344

  Fly   360 STFSLIVNELGLLFLFGQNKKTGEANMYPKPVQDLSGWNITDIGC-ANTSIMISADDTLIAWGAS 423
            ..:||...|.|.|.| |:.   .|....|..:..|..  ::.:.| |:....::.|..:.|||..
Human   345 KAYSLGRAEYGRLGL-GEG---AEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMG 403

  Fly   424 PTFGELGIGEFQKS-STVPKEVPKLDNIKIPQVTMGYSHTVLLV 466
            ..: :||.|:.:.: |.|.....:|:|..:..|:.|..||||||
Human   404 TNY-QLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLV 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	14/46 (30%)
		RCC1_2	171..200	CDD:290274	11/28 (39%)
		RCC1	188..236	CDD:278826	9/48 (19%)
		RCC1	239..312	CDD:278826	22/73 (30%)
		RCC1	317..366	CDD:278826	12/59 (20%)
		RCC1	414..465	CDD:278826	16/51 (31%)
RCC1	NP_001041659.1	RCC1	66..113	CDD:278826	14/54 (26%)
		RCC1	116..165	CDD:278826	14/51 (27%)
		RCC1	168..218	CDD:278826	9/49 (18%)
		RCC1	221..286	CDD:278826	22/73 (30%)
		RCC1	289..340	CDD:278826	8/50 (16%)
		RCC1	343..386	CDD:278826	12/48 (25%)
		RCC1	394..445	CDD:278826	16/51 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910