DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and Ibtk

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001074751.1	Gene:	Ibtk / 108837	MGIID:	1918677	Length:	1352	Species:	Mus musculus

Alignment Length:	374	Identity:	84/374 - (22%)
Similarity:	136/374 - (36%)	Gaps:	72/374 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 HTILINMDRKALGFGRNPSGQLGLSQDIKLAEKPTIIPALEQLNIVQAAVGRHHTLFLTDTGTVY 191
            |::.::...:....|....|:|| ..|.:....|.::..|...|..|.|..:.||:.|||.|.||
Mouse   188 HSVFLSQKGQVYTCGHGRGGRLG-HGDEQTCLVPRLVEGLSGHNCSQVAAAKDHTVVLTDDGCVY 251

  Fly   192 ACGENKSGQCGVGNTHANIYSPTPIN---YRGPPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQL 253
            ..|.|...|.|:....|:...|..|.   .:|..||.:..| .|..:|..:.:::|.|| ..|||
Mouse   252 TFGLNMFHQLGIIPPPASCNVPRQIQAKYLKGRTIIGVAAG-RFHTVLWTREAVYTLGL-NGGQL 314

  Fly   254 GHNTDAKYFVNANKLSFHFETSPKKV-VLYIEKSKEGHVTPVDGVQI-----------VDFACGN 306
            ||..|.    |..|.    .|:|::| .|:.:......|...||..:           .|:.|..
Mouse   315 GHLLDP----NGEKC----VTTPRQVSALHHKDIAVSLVAASDGATVCVTTRGDIYLLADYQCKK 371

  Fly   307 NHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDTQGRGGRSVFCGSTFSLIVNELGL 371
            ..|..::.||.:.|.|...:    ..:|:........|.......|...|||..:.|..:.:...
Mouse   372 MATKQLNLKKVLVSGGCMEY----KVDPEHLTENGGQKICVLAMDGAGRVFCWRSISSSLKQCRW 432

  Fly   372 LFLFGQNKKTGEANMYPKPVQDLSGWNITDIGCANTSIMISADDTLIAWGASPTFGELGIGEF-- 434
                          .||:.|      :|:||......|:....|           ||...|::
Mouse   433 --------------AYPRQV------SISDIALNRNEILFVTQD-----------GEGFKGKWFE 466

  Fly   435 --QKSSTVPKEVPKLDNIKIPQVTMGYSHTVLLVDTTHEATKQKYEKMP 481
              :|:|....::       :|.:....|....:.||.....:.:.||:|
Mouse   467 DKRKNSEKKADI-------LPNLHHSSSDVSCVPDTNSVYERIRLEKLP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	12/44 (27%)
		RCC1_2	171..200	CDD:290274	12/28 (43%)
		RCC1	188..236	CDD:278826	15/50 (30%)
		RCC1	239..312	CDD:278826	21/84 (25%)
		RCC1	317..366	CDD:278826	9/48 (19%)
		RCC1	414..465	CDD:278826	8/54 (15%)
Ibtk	NP_001074751.1	Ank_2	25..116	CDD:289560
		ANK	<47..135	CDD:238125
		ANK repeat	51..82	CDD:293786
		ANK 1	51..80
		ANK repeat	84..116	CDD:293786
		ANK 2	85..114
		RCC1 1	141..194		1/5 (20%)
		RCC1	143..192	CDD:278826	1/3 (33%)
		RCC1 2	195..246		13/51 (25%)
		RCC1_2	232..260	CDD:290274	12/27 (44%)
		RCC1	247..299	CDD:278826	15/52 (29%)
		RCC1 3	248..301		16/53 (30%)
		BTB	562..>643	CDD:279045
		BTB	566..>643	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..716
		BTB	762..868	CDD:279045
		BTB	770..872	CDD:197585
		SPOP_C_like	872..>919	CDD:269810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1094
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900