DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and rcc2

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_031761501.1	Gene:	rcc2 / 100494942	XenbaseID:	XB-GENE-996297	Length:	513	Species:	Xenopus tropicalis

Alignment Length:	519	Identity:	226/519 - (43%)
Similarity:	310/519 - (59%)	Gaps:	47/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKRKAGGNGAGPNKRRP---------KKKESDYEDEFSDESDD-------DGVQQ-------- 41
            |..|:...|:|.|....||         .||.|  ..|||.:.||       ||..|
Frog     1 MPRKKVTEGSGPGNGAARPGSRKKAAASAKKRS--RQEFSSDDDDLDGSPGSDGGFQGNNNKRGP 63

  Fly    42 -QAAAANQMEVLIPHDDLDPPSKLPEDLLATLEKTPGQMLIAGMVTWDLTGKRDRKNVTK----- 100
             :.||.....|::..     |....|.:.....|..||:||.|...|||.|   ||.|.|
Frog    64 AKGAAKAPTAVIVTE-----PEHSKEKIKLEGSKAKGQLLIFGATNWDLIG---RKEVPKQQAAY 120

  Fly   101 --VRPNLYSFHRF---TEEKYRYVASGPSAAHTILINMDRKALGFGRNPSGQLGLSQDIKLAEKP 160
              :..||:..||:   |..:.|.||:||.|||::||.::.|...:|||..|||| ..|:|..:.|
Frog   121 RNLGQNLWGPHRYGCLTGVQVRTVAAGPCAAHSLLITVEGKLWSWGRNDKGQLG-HGDVKRIDVP 184

  Fly   161 TIIPALEQLNIVQAAVGRHHTLFLTDTGTVYACGENKSGQCGVGNTHANIYSPTPINYRGPPIIR 225
            .:|.:|:....|..|.||:|||.||:.|:|||.||||.||.|:||....:.||..|.|.|.||.:
Frog   185 KLIESLKGEVFVHGACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQILYNGQPITK 249

  Fly   226 IGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVVLYIEKSKEGH 290
            :.||||||:|:|.||:|::||.|||||||||:|.||...|.::.:..|...:::.::|||:|:|.
Frog   250 VACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIAIFIEKTKDGQ 314

  Fly   291 VTPVDGVQIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDTQGRGGRS 355
            |.||..|.:.|.|||.||::.:||:|||:||||||:|||||:|.:|||||||:|.||..|||...
Frog   315 VLPVPNVVVRDIACGINHSLVLDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLVKLFDFPGRGASQ 379

  Fly   356 VFCGSTFSLIVNELGLLFLFGQNKKTGEANMYPKPVQDLSGWNITDIGCANTSIMISADDTLIAW 420
            ::.|:|.|..|:|:|.||.:|....:.::.||||.||||.||.:.::.|..:||:::||::.|:|
Frog   380 IYAGATCSFAVSEMGGLFFWGATNTSRDSTMYPKTVQDLCGWKVRNLACGKSSIILAADESTISW 444

  Fly   421 GASPTFGELGIGEFQ-KSSTVPKEVPKLDNIKIPQVTMGYSHTVLLVDTTHEATKQKYEKMPEY 483
            |.||||||||.|:.: ||||..:||..||.|...||.||||||:::.....|..|:|.:|:|||
Frog   445 GPSPTFGELGYGDNKAKSSTTAQEVKTLDGIYSDQVCMGYSHTLVVARDETEQDKEKLKKLPEY 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	19/44 (43%)
		RCC1_2	171..200	CDD:290274	17/28 (61%)
		RCC1	188..236	CDD:278826	26/47 (55%)
		RCC1	239..312	CDD:278826	34/72 (47%)
		RCC1	317..366	CDD:278826	30/48 (63%)
		RCC1	414..465	CDD:278826	30/51 (59%)
rcc2	XP_031761501.1	ATS1	122..472	CDD:227511	171/350 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11747
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10282
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1828
OMA	1	1.010	-	-		QHG54771
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0006921
OrthoInspector	1	1.000	-	-		oto104987
Panther	1	1.100	-	-	LDO	PTHR46207
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5530
SonicParanoid	1	1.000	-	-		X4391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110