DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and als2b

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_009300450.1	Gene:	als2b / 100318899	ZFINID:	ZDB-GENE-080929-1	Length:	1706	Species:	Danio rerio

Alignment Length:	417	Identity:	91/417 - (21%)
Similarity:	137/417 - (32%)	Gaps:	156/417 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DLTGKRDRKNVTKVRPNLYSFHRFTEEKYRYVASGP------SAAHTILINMDRKALGFGRNPSG 146
            |.:|:|...:..|.    ||:....|   |.:.|.|      .|.|.:|:....:...|     |
Zfish    11 DSSGERGLLHTWKG----YSYSTAPE---RVLLSRPVLQAALGARHGVLLVEGGQVYSF-----G 63

  Fly   147 QLGLSQDIKLAEKPTIIPALEQLNIVQAAVGRHHTLFLTDTGTVYACGENKSGQCGVGNTHANIY 211
            :|...|:...:.:|.:...|.:..:|..|.|..|:..:|:.|.|:..|||..||||:..... |.
Zfish    64 ELPWKQNQTSSAEPILEAVLSEQRVVFVAAGSAHSGVVTEDGGVHMWGENVHGQCGLLGLSV-IP 127

  Fly   212 SPTPINYRGPPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKYFVNANKLSFHFETSP 276
            :|||:.                 :||
Zfish   128 NPTPVG-----------------VLD--------------------------------------- 136

  Fly   277 KKVVLYIEKSKEGHVTPVDGVQIVDFACGNNHTVAIDSKKRVYSWGFG---GFGRLGHAEPKDEM 338
                        ...||...|:|::.|||:.||:|:.:|..|::||.|   |.........|.:.
Zfish   137 ------------SEATPPQTVKILEVACGDQHTLALSAKHEVWAWGSGCQLGLNTSTFPVWKPQK 189

  Fly   339 VPRLMKFFDTQGRGGRSVFCGSTFSLIVNELGLLFLFGQNKKTGEANMYP------KPVQDLSG- 396
            |..|      .||....|.|||..|:.:                 ....|      ||.||..|
Zfish   190 VDHL------SGRHVLQVACGSAHSVAL-----------------VRCLPPPQEPRKPPQDKCGQ 231

  Fly   397 -----WNITDIGCANTSIMIS----------ADDTLI--AWGASPTFGELGIGEFQKSSTVP--- 441
                 :.:||   ....::||          .|.|.|  |...||..|:.|    :.|.|.|
Zfish   232 CHQLLYTMTD---KEDHVIISDGHHCPLGVEMDSTEIKSAVEGSPDPGKPG----KSSPTEPVPC 289

  Fly   442 -----KEVPKLDNI----KIPQVTMGY 459
                 .:.|...||    :.|:.|:.:
Zfish   290 MSTQISKSPTSSNISESTRPPESTLPF 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	10/44 (23%)
		RCC1_2	171..200	CDD:290274	10/28 (36%)
		RCC1	188..236	CDD:278826	13/47 (28%)
		RCC1	239..312	CDD:278826	9/72 (13%)
		RCC1	317..366	CDD:278826	15/51 (29%)
		RCC1	414..465	CDD:278826	16/60 (27%)
als2b	XP_009300450.1	RCC1_2	88..117	CDD:290274	10/28 (36%)
		RCC1	104..160	CDD:278826	24/124 (19%)
		RCC1	165..211	CDD:278826	15/51 (29%)
		RCC1	567..614	CDD:278826
		RCC1	619..665	CDD:278826
		PH_alsin	952..1065	CDD:241423
		COG4642	1085..1290	CDD:226989
		MORN	1104..1124	CDD:280628
		MORN	1153..1173	CDD:197832
		VPS9	1603..1702	CDD:280383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900