Protein Alignment IPIP and PLEKHA3

DIOPT Version :10

• Sequence 1: NP_608984.2
• Gene: IPIP / 33849
• FlyBaseID: FBgn0031768
• Length: 296
• Species: Drosophila melanogaster
• Sequence 2: NP_061964.3
• Gene: PLEKHA3 / 65977
• HGNCID: 14338
• Length: 300
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 55/275 - (20%)
• Similarity: 99/275 - (36%)
• Gaps: 67/275 - (24%)

  Fly    19 MEGFLNKRGEVNKAFQRRYFVLKGNLLFYFESRLD--KEPLGLIIVEGCTIELSNEVDNYCFEIA 81
            |||.|.|.......:|.|:|||...:|.|::|:.|  |...|.|.:..|.|:: :..||...|:.
Human     1 MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKV-HSADNTRMELI 64

  Fly    82 FNGNRTYILAAENQDSMETWMKALTCAGYEYKRIILAELKRQLQEMEDARNKMLGSALDGPQNAS 146
            ..|.:.:.:.|.|....:.|:            :.|...|..|.:....:.|.:       ...|
Human    65 IPGEQHFYMKAVNAAERQRWL------------VALGSSKACLTDTRTKKEKEI-------SETS 110

  Fly   147 ESAKPRPPPRRT-----------------NPFNRPAPPPPD----SSLRGGVVMSPLPFINGYFG 190
            ||.|.:....|.                 :..|..:|...:    |||......:.:..:.....
Human   111 ESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVK 175

  Fly   191 SSNARLQQEKLMSKQDANGNGSPSGTPRAQRRPTPAPAIANSVFYP----------DVRDPGAAN 245
            .:||:.:.|.....     :..|..:|.:   |:|...:..||.:|          .:::|
Human   176 IANAKFKPEMFQLH-----HPDPLVSPVS---PSPVQMMKRSVSHPGSCSSERSSHSIKEP---- 228

  Fly   246 NNHSTVNGAERQRRQ 260
              .||::...::||:
Human   229 --VSTLHRLSQRRRR 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IPIP	NP_608984.2	PH_Ses	11..127	CDD:270105	29/109 (27%)
PLEKHA3	NP_061964.3	PH_FAPP1_FAPP2	1..100	CDD:269951	29/111 (26%)
		Interaction with SACM1L. /evidence=ECO:0000269|PubMed:30659099	1..100		29/111 (26%)
		Interaction with VAPA and VAPB. /evidence=ECO:0000269|PubMed:30659099	97..300		26/166 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	197..300		11/54 (20%)