Protein Alignment mtm and MTMR4

DIOPT Version :10

• Sequence 1: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001364996.1
• Gene: MTMR4 / 9110
• HGNCID: 7452
• Length: 1209
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 202/585 - (34%)
• Similarity: 296/585 - (50%)
• Gaps: 114/585 - (19%)

  Fly    46 PFGYLEGEEDQDQKNDVTYVCPYRGPVFGAL-TITNYRLYFRSLPLRDQEPPVVVDVPLGVIARV 109
            ||..|:||..:           :.|....|| .|:||||:.:   .:|.    |::|||.:|..|
Human    47 PFTVLQGEGVE-----------FLGRAADALIAISNYRLHIK---FKDS----VINVPLRMIDSV 93

  Fly   110 EKIGGATSRGENSYGIEIFCKDMRNLR-----FAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAF 169
            |        ..:.:.:.|.|||.:.:|     |...|:..||.:     :|.|.|..... ||||
Human    94 E--------SRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLS-----RATARPAKPED-LFAF 144

  Fly   170 AHAAANSVNGNGGWDGWA-----------VYEP--------LAELRRLGVP-NDMWRATKLNESY 214
            |:.|            |.           :.:|        .|||.|:|.. .::||.:.:|.:|
Human   145 AYHA------------WCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNY 197

  Fly   215 AICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDD 279
            .:|.|||....||...:|..|..||.|||..|:||:.:.:.|..|.|.|||||.:...|.||:||
Human   198 KLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADD 262

  Fly   280 EAYLSFI-----------------------------------------MEANAQSDKLTIMDARP 303
            |..::.|                                         :|:.|...||.|:|||.
Human   263 EYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTACSGVESTAAPQKLLILDARS 327

  Fly   304 SANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTLW 368
            ...|:||:|||||.|.|:.|.|.|:.|:.:.|||.:|.|.:.::..|....|.|.|.:|:::|.|
Human   328 YTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKW 392

  Fly   369 LKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEW 433
            |:|:..:|..||.:.:.|:.....|:||||||||||.|:.||:.:||||:|||:.||:||:|.:|
Human   393 LQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDW 457

  Fly   434 LSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFG 498
            |.|||||..|.||.:|.....::.|||||::|||.|:.:||...|||||.||:.:|.|.|||.:|
Human   458 LDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYG 522

  Fly   499 TFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLY 563
            |||.|...||...::..:|.|:|..:.:....:.|.|   :|..:::||.|:..||::.||..:|
Human   523 TFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFL---YTPSSDMVLHPVCHVRALHLWTAVY 584

  Fly   564  563
            Human   585  584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	27/107 (25%)
		Myotub-related	184..509	CDD:461958	148/385 (38%)
MTMR4	NP_001364996.1	PH-GRAM_MTMR4	37..150	CDD:270150	39/146 (27%)
		PTP-MTMR4	186..493	CDD:350435	120/306 (39%)
		FYVE_MTMR4	1125..1184	CDD:277272