Protein Alignment mtm and MTMR6

DIOPT Version :9

• Sequence 1: NP_001285651.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001372159.1
• Gene: MTMR6 / 9107
• HGNCID: 7453
• Length: 659
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 198/564 - (35%)
• Similarity: 294/564 - (52%)
• Gaps: 70/564 - (12%)

  Fly   106 IARVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFA 170
            ||.|||:...||    ...:.|.||:.|.:.|...::... ..::..|...:....|.. |:||:
Human    53 IASVEKLALTTS----GCPLVIQCKNFRTVHFIVPRERDC-HDIYNSLLQLSKQAKYED-LYAFS 111

  Fly   171 HAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFL 235
            :....  |.:....||.:.:...|.:|:||||..|:.:..|..|.||::||....||:.||...:
Human   112 YNPKQ--NDSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPII 174

  Fly   236 RRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIMD 300
            ...::|||:.|.||||:.:...:|.|.||||||.|.|. |..:||..|..|.:||..:..:.:||
Human   175 VGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSA-RCLEDEHLLQAISKANPVNRYMYVMD 238

  Fly   301 ARPS--------------------------------------ANAIANKAKGGGYESEDAYKNVE 327
            .||.                                      .||:||:|.|.|||:||.|.|:.
Human   239 TRPKRRMQSWWATQKDIGRIIVRISSKIQNDEKIRESNEKKRLNAMANRAAGKGYENEDNYSNIR 303

  Fly   328 INFLDIHNIHVMRESLRKVKEACFPTTDDSK------WQTAIDNTLWLKHIRCILAGAVRIVDKV 386
            ..|:.|.||||||.||:|:.|     .:.:|      :.:.::::.||:||:.::..|:.:...:
Human   304 FQFVGIENIHVMRSSLQKLLE-----VNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAI 363

  Fly   387 ETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGH--GDN 449
            ...:.||:||||||||||:|:.:|..||||.:|||::||.|||||:|:||||||.:|.|.  ||.
Human   364 TVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDP 428

  Fly   450 KHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLK 514
            |    :.||||.||::.||.:::||..||||:|.||:.|.:|::||:||.||.|.:.||....||
Human   429 K----EVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLK 489

  Fly   515 HKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLYCRWNPGLCAPQHGCQR 579
            .||.|||..:.....:|||||:.|.:| ...||.|.....:.:.|:.:|.:::..|...|.....
Human   490 EKTYSLWPFLLEDQKKYLNPLYSSESH-RFTVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNI 553

  Fly   580 TRELLSKQDQLFKLVNELRLKSNNRSNSMQT----TTRLASPMH 619
            ...:..:..||.|.:.:|..|...|.|. ||    |..|...:|
Human   554 IMNMNEQNKQLEKDIKDLESKIKQRKNK-QTDGILTKELLHSVH 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	13/52 (25%)
		Myotub-related	184..509	CDD:399535	146/370 (39%)
MTMR6	NP_001372159.1	PH-GRAM_MTMR6	1..101	CDD:270151	13/52 (25%)
		PTP_DSP_cys	130..469	CDD:421693	136/348 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155560
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1956
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.880