Protein Alignment mtm and MTMR2

DIOPT Version :10

• Sequence 1: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_057240.3
• Gene: MTMR2 / 8898
• HGNCID: 7450
• Length: 643
• Species: Homo sapiens
• Alignment Length: 649
• Identity: 360/649 - (55%)
• Similarity: 467/649 - (71%)
• Gaps: 49/649 - (7%)

  Fly     1 MDPSASLADKLASKTA-----SSNSLDSSSKSSSLGSKH-------------GGGEN-----GIL 42
            |:.|:| .:.|.|:.|     |.:||.|:|.|.|..|.|             ...:|     .:|
Human     1 MEKSSS-CESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFSPDLRVL 64

  Fly    43 RDT---------PFGYLEGEEDQDQKNDVTYVCPYRGPVFGALTITNYRLYFRSLPLRDQEPPVV 98
            |::         |.  |.||..:|...||||:||:.|.|.|.||:|||||||:|:   :::||.|
Human    65 RESNKLAEMEEPPL--LPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSM---ERDPPFV 124

  Fly    99 VDVPLGVIARVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYS 163
            :|..||||.||||||||:||||||||:|..|||:||||||||.:..:||::||.|...|||:|.:
Human   125 LDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNN 189

  Fly   164 GRLFAFAHAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPK 228
            ..||||.:......|      ||.:|:||.|.||.|:||:.||.||:||.|.:||:|||:..||.
Human   190 LPLFAFEYKEVFPEN------GWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPA 248

  Fly   229 AASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQS 293
            ...|:.|:|||.||||.|:|||||::|.:||||||||||:|||||||:.:||.||..||::||||
Human   249 NIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQS 313

  Fly   294 DKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSK 358
            .|:.|.|||||.||:|||||||||||||||:|.|:.||||||||||||||||:||..:|..:::.
Human   314 HKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETH 378

  Fly   359 WQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVR 423
            |.:.:::|.||:||:.|||||:||.||||:..||||||||||||||||||:|:||:||.:|||:|
Human   379 WLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIR 443

  Fly   424 GFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITI 488
            |||||:|||||||||:||.|:||||..|:|||||||||||||.|||:::||..||||||:|||||
Human   444 GFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITI 508

  Fly   489 VDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASV 553
            :||||||.|||||||:|.:|..|:|..:|.|||::|||.|:.:.|||:.|:::.   ||.|:||:
Human   509 LDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNH---VLYPVASM 570

  Fly   554 RSVRLWKGLYCRWNPGLCAPQHGCQRTRELLSKQDQLFKLVNELRLKSNNRSNSMQTTTRLASP 617
            |.:.||.|.|.||||.:...:....|.:|||:|:.:|.|.|.||:.:.:|||.|  ::.|.:||
Human   571 RHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRSTS--SSERASSP 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	62/101 (61%)
		Myotub-related	184..509	CDD:461958	222/324 (69%)
MTMR2	NP_057240.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		15/55 (27%)
		PH-like	73..187	CDD:473070	68/118 (58%)
		Myotub-related	202..528	CDD:461958	223/331 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..643		7/20 (35%)