Protein Alignment mtm and MTMR1

DIOPT Version :10

• Sequence 1: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_005274822.1
• Gene: MTMR1 / 8776
• HGNCID: 7449
• Length: 699
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 321/645 - (49%)
• Similarity: 444/645 - (68%)
• Gaps: 46/645 - (7%)

  Fly     4 SASLADKLASKTASSN--------------SLDSSSKSSSLGSKHGG-----GENGILRD-TPFG 48
            :|:::.:::....|.|              ::..:.:...:..:|.|     ..:..||| ....
Human    63 AATISSQISGSVTSENVSRDYKVFRRPDLRNIHKARQRLEIQEEHNGYPSEAEADQALRDGNKLA 127

  Fly    49 YLE------GEEDQDQKNDVTYVCPYRGPVFGALTITNYRLYFRSLPLRDQEPPVVVDVPLGVIA 107
            .:|      ||..:....||.|:||:.|.|.|.||:|:::|||:::   :::|..::|||||||:
Human   128 QMEEAPLFPGESIKAIVKDVMYICPFMGAVSGTLTVTDFKLYFKNV---ERDPHFILDVPLGVIS 189

  Fly   108 RVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHA 172
            ||||| ||.|.|:||.||||.||||||||.|:||:..|:..:||.|..:|||||....||||::.
Human   190 RVEKI-GAQSHGDNSCGIEIVCKDMRNLRLAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSYK 253

  Fly   173 AANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRR 237
            ....:|      ||.||:|::|.:|.|:||:.|:.:|:|.:|..||:|||:..||.:..||.|.:
Human   254 EKFPIN------GWKVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSK 312

  Fly   238 VAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIMDAR 302
            ||.||::.|:|||||::|.:|||||||||||||.:.||..:||.||..||:|||||.||.|.|||
Human   313 VAAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDAR 377

  Fly   303 PSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTL 367
            .::.|..||.||||||||.||.|.|:.||:|||||||||||||:||..:|:.|:::|.:.:|.|.
Human   378 QNSVADTNKTKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEARWLSNVDGTH 442

  Fly   368 WLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKE 432
            ||::||.:|||||||.||:|:..||||||||||||||||||:|:||:||.:|||::|||.|:|||
Human   443 WLEYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLVEKE 507

  Fly   433 WLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRF 497
            |:||||:|..|:|||::.|:||||||:||||:|.|||:::||.:||||||.|||||:||||||.|
Human   508 WISFGHRFALRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLF 572

  Fly   498 GTFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGL 562
            ||||||.|.:|..||:..||.|||::|||.||::.||.|.::.:.   ||.|:||:..:.||...
Human   573 GTFLCNCEQQRFKEDVYTKTISLWSYINSQLDEFSNPFFVNYENH---VLYPVASLSHLELWVNY 634

  Fly   563 YCRWNPGLCAPQ---HGCQRTRELLSKQDQLFKLVNELRLKSNNRSNSMQTTTRLASPMH 619
            |.||||.: .||   |  |..:|||:.:.:|.|.|..|:.:...|:.| .::.|.:||.|
Human   635 YVRWNPRM-RPQMPIH--QNLKELLAVRAELQKRVEGLQREVATRAVS-SSSERGSSPSH 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	53/101 (52%)
		Myotub-related	184..509	CDD:461958	203/324 (63%)
MTMR1	XP_005274822.1	PH-GRAM_MTMR1	141..240	CDD:270165	53/102 (52%)
		Myotub-related	257..583	CDD:461958	204/331 (62%)