Protein Alignment mtm and YMR1

DIOPT Version :10

• Sequence 1: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_012644.1
• Gene: YMR1 / 853574
• SGDID: S000003871
• Length: 688
• Species: Saccharomyces cerevisiae
• Alignment Length: 674
• Identity: 196/674 - (29%)
• Similarity: 292/674 - (43%)
• Gaps: 167/674 - (24%)

  Fly    74 GALTITNYRLYFRSLPLRDQEPPVVVD--VPLGVIARVEKIGGAT--SRGENSYGIEIFCKDMRN 134
            |.|.:|.:.|.|.|       |.:..:  .|..:|..|.|..|:|  |:..::..|::...|.:|
Yeast    23 GTLHLTTHHLIFES-------PQLSTEFWFPYPLIYGVHKNPGSTLLSKLTSTNQIQLEGTDSQN 80

  Fly   135 LRF-----------------------------AHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFA 170
            .:.                             .|.|    .|.|::.: .|...||...:|:||.
Yeast    81 YKLYQGKDLWSFVNIKVIGKDYAVFSLDFGGDLHLQ----ARKVYDSI-LNLTVLSNITQLYAFI 140

  Fly   171 HAAANSVNGNGGWDGWAVYEPLAELRRLGVPND----MWRATKLNESYAICDSYPAVWAVPKAAS 231
            :.:.|........|.|.:|:|:.|.||.|:.:.    .||.:.:||.|..|.:||:...||::.|
Yeast   141 YISNNLERKLPSPDSWDIYDPIKEFRRQGLDSKDETCPWRLSTVNEHYEFCPTYPSKLFVPRSTS 205

  Fly   232 DDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDD-----EAYLSFIMEANA 291
            |..|:..::|||:.|:|||::.:..|...|.|.||||.|:..:|:..|     |::.|| ...:.
Yeast   206 DILLKHASKFRSQKRIPVLTYHHKATDCNILRSSQPLPGLINQRSIQDEKLVWESFNSF-CNKDI 269

  Fly   292 QSDKLTIMDARPSANAIANKAKGGGYESEDAY------KNVEIN-----------FLDIHNIHVM 339
            :..|..|:||||..||:|..|.|||.|:.|.|      .|:.::           ||.|.|||::
Yeast   270 RRTKHVIVDARPRTNALAQMALGGGTENMDNYNFFLADNNMGVDKSLKLPTVTRLFLGIDNIHIV 334

  Fly   340 RESLRKVKEA-C------FPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHC 397
            ..:...:.|. |      .|...:........|  |||....||.....::..:....::|:|||
Yeast   335 SNTAAYMTEVICQGGDLNLPLEQNLIRSQKFSN--WLKLNTLILKSVDMLLKSIIFNHSNVLVHC 397

  Fly   398 SDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGH---------------- 446
            |||||||:|:.:|..:.|||.|||..||.:|:||:|.||||:|.:|.||
Yeast   398 SDGWDRTSQVVSLLEICLDPFYRTFEGFMILVEKDWCSFGHRFLERSGHLNSDIRFHDNTMHSNF 462

  Fly   447 ------GD-----------------------------------------NKHSDADRSPVFLQFI 464
                  ||                                         ||.|....||||.||:
Yeast   463 NDVDTNGDDLDIGVNTQDDYAEDDEGGEDETNLINLSRISKKFNENFKLNKKSLKFVSPVFQQFL 527

  Fly   465 DSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHINSSLD 529
            |.|:|:..|..:.|||||.||..:|.|||||::||||.|:|.|:..::|.:||.|:|.:..|...
Yeast   528 DCVYQLLTQNPDLFEFNERFLRRLVYHLYSCQYGTFLSNSEKEKFQQNLPNKTKSVWDYFRSRRK 592

  Fly   530 QYLNPLFPSFTHGA-----------ELVLRPIASVRSVRLWKGLYCRWNPGLCAPQHGCQRTREL 583
            |::||.|.......           |.|......::.|:.|..||.|         ...:...||
Yeast   593 QFINPNFIQRKRSGMNEHDQNLEEEEKVEWISPDLKKVQWWWQLYGR---------KDSEMNDEL 648

  Fly   584 LSKQDQLFKLVNELRLKSNNRSNS 607
            ..|:|.:...|::   ||...|||
Yeast   649 RHKRDSVPISVDK---KSKEHSNS 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	22/117 (19%)
		Myotub-related	184..509	CDD:461958	141/420 (34%)
YMR1	NP_012644.1	PH-like	1..>44	CDD:473070	7/27 (26%)
		Myotub-related	152..570	CDD:461958	140/420 (33%)