DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and MTM1

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_187666.5	Gene:	MTM1 / 820220	AraportID:	AT3G10550	Length:	840	Species:	Arabidopsis thaliana

Alignment Length:	604	Identity:	199/604 - (32%)
Similarity:	285/604 - (47%)	Gaps:	136/604 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 GALTITNYRLYFRSLPLRDQEPPVVVDVPLGVI--ARVEKIGGATSRGENSYG----------IE 126
            |.|.:||:|:.|.|...|..       :|||.|  |.:||......:.::|..          ::
plant    75 GTLLVTNFRILFLSEGTRKV-------IPLGTIPLATIEKFNKMVLKVQSSPRQSDKIPPRRLLQ 132

  Fly   127 IFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAAANSVNGNGGWDGWAVYEP 191
            :..||||.:.:..:.:...||.||:.|.....| .....|:.||...:...|.|          |
plant   133 VTGKDMRIIVYGFRPRTKQRRNVFDALLKCTKP-ERVWDLYTFACGPSKFGNAN----------P 186

  Fly   192 LAEL-----RRLG-----------------VPNDMWRATKLNESYAICDSYPAVWAVPKAASDDF 234
            ...|     |.||                 :.|::||.:.||.:|.:|.:||..:.:||:.||..
plant   187 KERLLNEYFRLLGKSSIRASMDMIEDGAFTLSNELWRISDLNSNYNLCQTYPFAFMIPKSISDAE 251

  Fly   235 LRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVG--VSGKRNSDDE---AYLSFIMEANAQSD 294
            |.:...||:||||||::|..|.:.|.|.|.||||||  ::.:.|.|::   |:.|.:..|..:..
plant   252 LLQACSFRARCRLPVITWCQPGSGAVIARSSQPLVGLMMNMRSNLDEKLVAAFCSQLPGAKGERR 316

  Fly   295 KLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEAC---FPTTDD 356
            ||.|.||||..||:||.|.|||.||...|...||.|..|.|||.||||..:|::..   ..|:.|
plant   317 KLYIADARPRKNALANGAMGGGSESSSNYFQSEIVFFGIDNIHAMRESFSRVRDYLDMHGTTSSD 381

  Fly   357 SK--------WQ-------------TAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDG 400
            .:        |.             :.:.::.||.||:.:||||..|..:|...|.||:||||||
plant   382 GRSSFLRHGGWTWGGGNLSSMSASVSLLGDSGWLIHIQSVLAGAAWIAARVAMESASVLVHCSDG 446

  Fly   401 WDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIG-------------------- 445
            ||||.||.:|:.|||||:|||..||:.|:||:||:|||.|..|:|
plant   447 WDRTTQLVSLACLLLDPYYRTFAGFQALVEKDWLAFGHPFSDRVGMPNISGSGNFDFPRQSSSAG 511

  Fly   446 ----------------------HGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITI 488
                                  ||.|.:     ||:|:|:||||.|:.:.:..||||:..||:..
plant   512 SFPSSPVRQSSGSAASQSSSSSHGHNNY-----SPIFMQWIDSVSQLMRMYPCAFEFSPTFLVDF 571

  Fly   489 VDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHI------NSSLDQYLNPLFPSFTHGAELVL 547
            :|.|.|||||.||||:|.||....:......||.::      :::...:.||.:....:...| |
plant   572 MDCLLSCRFGNFLCNSEKEREQCGIADACGCLWAYLTDLRSFSATSHVHCNPFYDPLKYDGPL-L 635

  Fly   548 RPIASVRSVRLWKGLYCRW 566
            .|.||: :..||...:.||
plant   636 PPAASL-APTLWPQFHLRW 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	25/96 (26%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	154/417 (37%)
MTM1	NP_187666.5	GRAM	52..111	CDD:214725	15/42 (36%)
MTM1	NP_187666.5	Myotub-related	218..591	CDD:399535	148/377 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	268	1.000	Domainoid score	I445
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H22951
Inparanoid	1	1.050	285	1.000	Inparanoid score	I854
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		mtm1152
orthoMCL	1	0.900	-	-		OOG6_101490
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.870