DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and Sbf1

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_006521601.1	Gene:	Sbf1 / 77980	MGIID:	1925230	Length:	1901	Species:	Mus musculus

Alignment Length:	825	Identity:	184/825 - (22%)
Similarity:	305/825 - (36%)	Gaps:	293/825 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 PVFGALTITNYRLYFRSLPLRD--QEPPVVVDVPLGVIARVEKIGGATSRGE------------- 120
            |..||:.:|.||:.|..:|...  .|..||...|:..:.:.::|...|...:
Mouse   932 PAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRISVQTPVDQLLQDGLQLRSCTF 996

  Fly   121 -----------NSYGIEIFCKDMRNLRF--------------AH---------KQQNHSRRTVFE 151
                       .|...|:|.|.:..||:              ||         |.:..|.||:..
Mouse   997 QLLKMAFDEEVGSDSAELFRKQLHKLRYPPDIRATFAFTLGSAHTPGRPPRVTKDKGPSFRTLSR 1061

  Fly   152 KLQANAFPLSYSGRLFAFAHAAANSVNGNGGW------------DGWAVYEPL------------ 192
            .|..||  ....||.:     .........||            |..:|.|.|
Mouse  1062 NLMKNA--KKTIGRQY-----VTRKKYNPPGWEHRGQPPPEDQEDEISVSEELEPSTLTPSSALK 1119

  Fly   193 ----------------AELRRLGV----------PNDMWRATKLNESYAICDSYPAVWAVPKAAS 231
                            .:.:|||:          .::.:|.:.:|..||||.|||.:..||::..
Mouse  1120 PSDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSIQ 1184

  Fly   232 DDFLRRVAQFRSRCRLPVLSWMNPRTQATITRC----SQPLVGVSGKRNS-------------DD 279
            |:.|:||::...:.|.||:.|.:.|::|.:.|.    .:.:||:...:|:             :.
Mouse  1185 DNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNTPSPGQAQADSSSLEQ 1249

  Fly   280 EAYLSFIMEA------------------------------------------------------- 289
            |.||..::.:
Mouse  1250 EKYLQAVVSSMPRYADSSGRNTLSSFSSAHMGGHVPSPRARVTTLSNPLAASASRWTASRGKWSS 1314

  Fly   290 ------------------------------NAQSDKLTIMDARPSANAIANKAKGGGYESEDAYK 324
                                          .|..|...:...|.:...|.:||:..|.. .|..:
Mouse  1315 VRASGRSSGLGSDVGSRLAGRDLLSTPHTNGAPPDSGFLRPQRAALYIIGDKAQLKGVR-PDPLQ 1378

  Fly   325 NVEINFLDIHNIHVMRESLRKVKEACF---PTTDDS--KWQTAIDNTLWLKHIRCILAGAVRIVD 384
            ..|:..:::.....::.|.:|:.:||.   |.|:.|  .:..:::::.||..|..:|..:|.:|:
Mouse  1379 QWELVPIEVFEARQVKASFKKLLKACVPGCPATEPSPASFLRSLEDSEWLIQIHKLLQISVLVVE 1443

  Fly   385 KVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDN 449
            .::: .:||:|...||||.|.|:.:|..||.||.|||:.||.:|:|||||||||:|..|     .
Mouse  1444 LLDS-GSSVLVSLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHR-----G 1502

  Fly   450 KHSDADRS----PVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVA 510
            .|:.|.:|    ||||||:|.|.||..||...|||::.:|..:..|..|.||.|||.:::.||:.
Mouse  1503 AHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHTSRRFRTFLLDSDYERIE 1567

  Fly   511 EDLKHK----------TTSLWTHINSSLDQYLNPLFPSFTHGAE--LVLRPIASVRSVRLW---- 559
            ..|.::          ..|:|.:::....:  .|:|.::|:..|  .||||.::|.::::|
Mouse  1568 LGLLYEEKGERRGQLACKSVWEYVDRLSKR--TPMFYNYTYAPEDTEVLRPYSNVSNLKVWDFYT 1630

  Fly   560 -----KGLYCRW-------------NPGLCAPQH------GCQRTRELLSKQDQLFKLVNEL--- 597
                 :|....|             .|...|||.      .|..:|..: :.|.:.:|:.||
Mouse  1631 EETLAEGPPYDWELAQGPPEPPEEERPDGGAPQSRRRVVWPCYDSRPRV-QPDAISRLLEELQRL 1694

  Fly   598 ----------------RLKSNNRSNSMQ----TTTRL---ASPMH 619
                            |:|:..|..|.|    |.:.|   |.|.|
Mouse  1695 ETELGRPSERWKDTWDRVKAAQRLESRQDGRGTPSSLLVSAVPHH 1739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	29/136 (21%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	115/473 (24%)
Sbf1	XP_006521601.1	uDENN	1..86	CDD:214824
		DENN	129..318	CDD:214823
		dDENN	372..440	CDD:129037
		SBF2	551..772	CDD:372054
		PH-like	901..1019	CDD:388408	18/86 (21%)
		PTP_DSP_cys	1158..1530	CDD:391942	94/378 (25%)
		PH_Sbf1_hMTMR5	1794..1899	CDD:269941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846067
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840