Protein Alignment mtm and Mtmr2

DIOPT Version :10

• Sequence 1: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_036011299.1
• Gene: Mtmr2 / 77116
• MGIID: 1924366
• Length: 718
• Species: Mus musculus
• Alignment Length: 654
• Identity: 357/654 - (54%)
• Similarity: 464/654 - (70%)
• Gaps: 52/654 - (7%)

  Fly     1 MDPSASL----ADKLASKTASSNSLDSSSKSSSLGSKHGGGENGILRDT---------------- 45
            |:.|:|.    |...|::..|.:||.|:|.|.|..|.|....:.|..|:
Mouse    69 MEKSSSCESLGAQLPAARLPSEDSLSSASTSHSENSVHTKSASAISSDSISTSADNFSPDLRVLR 133

  Fly    46 ----------PFGYLEGEEDQDQKNDVTYVCPYRGPVFGALTITNYRLYFRSLPLRDQEPPVVVD 100
                      | ..|.||..:|...||||:||:.|.|.|.||:|:|||||:|:   :::||.|:|
Mouse   134 EANKLAEMEEP-ALLPGENIKDMAKDVTYICPFTGAVRGTLTVTSYRLYFKSM---ERDPPFVLD 194

  Fly   101 VPLGVIARVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGR 165
            ..||||:||||||||:||||||||:|..|||:||||||||.:..:||::||.|...|||:|....
Mouse   195 ASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNGLP 259

  Fly   166 LFAFAHAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAA 230
            ||||.:......|      ||.:|:||.|.||.|:||:.||.||:||.|.:||:|||:..||...
Mouse   260 LFAFEYKEVFPEN------GWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANI 318

  Fly   231 SDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDK 295
            .|:.|:|||.||||.|:|||||::|.:|||:||||||:|||||||:.:||.||..||::||||.|
Mouse   319 PDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHK 383

  Fly   296 LTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQ 360
            :.|.|||||.||:|||||||||||||||:|.|:.||||||||||||||||:||..:||.:::.|.
Mouse   384 IFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPTIEETHWL 448

  Fly   361 TAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGF 425
            :.:::|.||:||:.|||||:||.||||:..||||||||||||||||||:|:||:||.:|||:|||
Mouse   449 SNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGF 513

  Fly   426 EVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQ-------QFNNAFEFNEH 483
            |||:|||||||||:||.|:||||..|:|||||||||||||.|||:::       ||..||||||:
Mouse   514 EVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFVVLNLQFPTAFEFNEY 578

  Fly   484 FLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLR 548
            |||||:||||||.|||||||:|.:|..|:|..||.|||::|||.|:.:.|||:.|:::.   ||.
Mouse   579 FLITILDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLYGSYSNH---VLY 640

  Fly   549 PIASVRSVRLWKGLYCRWNPGLCAPQHGCQRTRELLSKQDQLFKLVNELRLKSNNRSNSMQTTTR 613
            |:||:|.:.||.|.|.||||.:...:....|.:|||:|:.:|.:.|.||:.:.:|||.|  ::.|
Mouse   641 PVASMRHLELWVGYYIRWNPRMKPQEPIHSRYKELLAKRAELQRKVEELQREISNRSTS--SSER 703

  Fly   614 LASP 617
            .:||
Mouse   704 ASSP 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	61/101 (60%)
		Myotub-related	184..509	CDD:461958	222/331 (67%)
Mtmr2	XP_036011299.1	PH-like	141..255	CDD:473070	67/117 (57%)
		Myotub-related	270..603	CDD:461958	223/338 (66%)