DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and mtmr1

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_012824024.1	Gene:	mtmr1 / 734091	XenbaseID:	XB-GENE-985305	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	636	Identity:	322/636 - (50%)
Similarity:	443/636 - (69%)	Gaps:	40/636 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SASLADKLASKTAS-----------------SNSLDSSSKSSSLGSKHGGGENGILRDTPFGYLE 51
            |:.::..:||:..|                 .|...|.|::..:..: .|.:...:.:.|.  ..
Frog    67 SSQISGPVASENVSRDYRVYKRPDLRDIQDEHNGFHSESETEQVALR-DGNKLAQMEEAPL--FP 128

  Fly    52 GEEDQDQKNDVTYVCPYRGPVFGALTITNYRLYFRSLPLRDQEPPVVVDVPLGVIARVEKIGGAT 116
            ||..:....||.|:||:.|.|.|.||:|::::||:::   :::||.::|||||||:||||| |..
Frog   129 GESIKAIAKDVMYICPFWGAVSGTLTVTDFKMYFKNV---ERDPPFILDVPLGVISRVEKI-GVQ 189

  Fly   117 SRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAAANSVNGNG 181
            |:|.:||||||.||||||||.|:||:..::..:||.|..||||:|....||||::....|||
Frog   190 SQGSHSYGIEIVCKDMRNLRLAYKQEEQNKLEIFENLIKNAFPVSNKLPLFAFSYKEKFSVN--- 251

  Fly   182 GWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCR 246
               ||.||:|.||.:|.|:||:.|:.||:|.:|.:||:||||:.||.:..|:...||..||::.|
Frog   252 ---GWKVYDPTAEYKRQGLPNESWKITKINNTYELCDTYPAVFVVPTSVLDEDFARVVAFRAKGR 313

  Fly   247 LPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIMDARPSANAIANK 311
            :|||||::|.:|||||||||||||.:.||..:||.||..||:|||||.||.|.|||.::.|..||
Frog   314 IPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNK 378

  Fly   312 AKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTLWLKHIRCIL 376
            .||||||||.||.|.|:.||:|||||||||||||:||..:|..|:::|.:.:|.|.||::||.:|
Frog   379 TKGGGYESESAYPNAELIFLEIHNIHVMRESLRKLKEIVYPAIDEARWLSNVDGTHWLEYIRMLL 443

  Fly   377 AGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQ 441
            ||:|||.|:||:..||||||||||||||||||:|:||:||.:|||::|||||:||||:||||:|.
Frog   444 AGSVRIADRVESSKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFEVLLEKEWISFGHRFA 508

  Fly   442 QRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEA 506
            .|:||||:.|:||||||:||||||.|||::.||..||||||.|||||:||||||.|||||.|:|.
Frog   509 MRVGHGDDNHADADRSPIFLQFIDCVWQMTNQFPAAFEFNELFLITILDHLYSCLFGTFLYNSEQ 573

  Fly   507 ERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLYCRWNPGLC 571
            :|:.|:::.||.|||::|||.:|::.||.:.::.|.   ||.|:||:..:.||...|.|||| ..
Frog   574 QRMKEEIQTKTLSLWSYINSHVDEFTNPFYVNYEHH---VLYPVASLSHLELWVNYYVRWNP-RT 634

  Fly   572 APQ---HGCQRTRELLSKQDQLFKLVNELRLKSNNRSNSMQTTTRLASPMH 619
            .||   |  |..::||:.:.:|.|.|.||:.::..||.| .::.|.:||.|
Frog   635 RPQMPIH--QNLKDLLAIRAELQKKVEELQREAATRSVS-SSSDRGSSPSH 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	52/101 (51%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	205/324 (63%)
mtmr1	XP_012824024.1	PH-GRAM_MTMR1	133..232	CDD:270165	52/102 (51%)
mtmr1	XP_012824024.1	Myotub-related	239..574	CDD:284109	212/340 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	475	1.000	Domainoid score	I434
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	667	1.000	Inparanoid score	I751
OMA	1	1.010	-	-		QHG58725
OrthoDB	1	1.010	-	-		D319276at33208
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		otm49224
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080