DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and SBF1

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_011529011.1	Gene:	SBF1 / 6305	HGNCID:	10542	Length:	1903	Species:	Homo sapiens

Alignment Length:	711	Identity:	164/711 - (23%)
Similarity:	274/711 - (38%)	Gaps:	238/711 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 PVFGALTITNYRLYFRSLPLRD--QEPPVVVDVPLGVIARVEKIGGATSRGE------------- 120
            |..||:.:|.||:.|..:|...  .|..||...|:..:.:.::|...|...:
Human   934 PAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRISVQTPVDQLLQDGLQLRSCTF 998

  Fly   121 -----------NSYGIEIFCKDMRNLRF--------------AH---------KQQNHSRRTVFE 151
                       .|...|:|.|.:..||:              ||         |.:..|.||:..
Human   999 QLLKMAFDEEVGSDSAELFRKQLHKLRYPPDIRATFAFTLGSAHTPGRPPRVTKDKGPSLRTLSR 1063

  Fly   152 KLQANAFPLSYSGRLFAFAHAAANSVNGNGGW------------DGWAVYEPL------------ 192
            .|..||      .:.....|......| ...|            |..:|.|.|
Human  1064 NLVKNA------KKTIGRQHVTRKKYN-PPSWEHRGQPPPEDQEDEISVSEELEPSTLTPSSALK 1121

  Fly   193 ----------------AELRRLGV----------PNDMWRATKLNESYAICDSYPAVWAVPKAAS 231
                            .:.:|||:          .::.:|.:.:|..||||.|||.:..||::..
Human  1122 PSDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQ 1186

  Fly   232 DDFLRRVAQFRSRCRLPVLSWMNPRTQATITRC----SQPLVGVSGKRNS-------------DD 279
            |:.|:||::...:.|.||:.|.:.|::|.:.|.    .:.:||:...:|:             :.
Human  1187 DNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQ 1251

  Fly   280 EAYLSFI-----------------------------------------MEANAQ----------- 292
            |.||..:                                         |.|:|.
Human  1252 EKYLQAVVSSMPRYADASGRNTLSGFSSAHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGS 1316

  Fly   293 --------------SDKLTIMD--ARPSANA-----------------IANKAKGGGYESEDAYK 324
                          ..:|...|  |.|.||.                 :.:||:..|..| |..:
Human  1317 VRTSGRSSGLGTDVGSRLAGRDALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRS-DPLQ 1380

  Fly   325 NVEINFLDIHNIHVMRESLRKVKEACFP-----TTDDSKWQTAIDNTLWLKHIRCILAGAVRIVD 384
            ..|:..:::.....::.|.:|:.:||.|     ....:.:..:::::.||..|..:|..:|.:|:
Human  1381 QWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVE 1445

  Fly   385 KVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDN 449
            .::: .:||:|...||||.|.|:.:|..||.||.|||:.||.:|:|||||||||:|..|     .
Human  1446 LLDS-GSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHR-----G 1504

  Fly   450 KHSDADRS----PVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVA 510
            .|:.|.:|    ||||||:|.|.||..||...|||::.:|..:..|..|.||.|||.:::.||:.
Human  1505 AHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIE 1569

  Fly   511 EDLKHK----------TTSLWTHINSSLDQYLNPLFPSFTHGAE--LVLRPIASVRSVRLW 559
            ..|.::          ..|:|.:::....:  .|:|.::.:..|  .||||.::|.::::|
Human  1570 LGLLYEEKGERRGQVPCRSVWEYVDRLSKR--TPVFHNYMYAPEDAEVLRPYSNVSNLKVW 1628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	29/136 (21%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	119/473 (25%)
SBF1	XP_011529011.1	uDENN	36..92	CDD:281455
		DENN	139..320	CDD:214823
		dDENN	374..442	CDD:129037
		SBF2	553..774	CDD:289132
		PH-GRAM_MTMR5	903..1021	CDD:275417	18/86 (21%)
		Myotub-related	1138..1566	CDD:284109	114/434 (26%)
		PH_Sbf1_hMTMR5	1796..1901	CDD:269941
		PH	1800..1901	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840