DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and sbf1

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_009298445.1	Gene:	sbf1 / 568277	ZFINID:	ZDB-GENE-040718-139	Length:	1936	Species:	Danio rerio

Alignment Length:	799	Identity:	176/799 - (22%)
Similarity:	296/799 - (37%)	Gaps:	298/799 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 PVFGALTITNYRLYF---------------RSLPLRD--QEPPVVVDVPL------GV------- 105
            |..||:.:|:|||.|               ||.|:..  :|..:.|.:|:      |:
Zfish   940 PAEGAIFLTSYRLIFKGTPTDPLVGEQVVTRSFPVASLTKEKRISVSLPMDQFIQEGLQLRSCTF 1004

  Fly   106 ----IARVEKIGGATSRGENSYGIEIFCKDMRNLRFAH----------------------KQQNH 144
                ||..|::....:        |:|.|.|..||:..                      |.:|.
Zfish  1005 QLMKIAFDEEVASDLA--------EVFRKHMHKLRYPQHVQGTFAFTVGQSAKLVVEHKTKDKNQ 1061

  Fly   145 SRRTVFEKLQANA--------------FPLSYSGRLFAFAHAAANSVNGNGGWDGWAVYEP---- 191
            |.:|:...|...|              .|.::..|         :|:......|..:|.|.
Zfish  1062 SLKTLSRNLVKTAKRTIGRQYVTRKKYSPPTWENR---------SSMQSEMDEDEISVSEEPEPS 1117

  Fly   192 ------------------------LAELRRLGV----------PNDMWRATKLNESYAICDSYPA 222
                                    ..:.:|||:          .|:.:|.:.:|..|.:|.|||.
Zfish  1118 SLTLSSTIRSSDRQTMSNVVERACCRDYQRLGLGTLSNSLTRSKNEPFRISTVNRMYTVCRSYPG 1182

  Fly   223 VWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCS------------QPLVGVSGKR 275
            :..||::..|..::|:.:...:.|.||:.|.|.||:|.:.|.:            .|....:|..
Zfish  1183 LLIVPQSIPDSTIQRICRCYRQNRFPVVCWRNSRTKAVLLRSAGLHAKGVVGFFKSPNAPTAGPS 1247

  Fly   276 NSD-----DEAYLSFI-----------------------MEANAQSDKL----------TIMDAR 302
            .:|     .|.||..|                       |..:..||||          .:|.|:
Zfish  1248 QADSTSLEQEKYLQAIISSMPSYSETSGRNTLSGFTSSHMSTSDSSDKLRQPKIGALMKQVMGAK 1312

  Fly   303 PS----------------------------------------------------ANAIANK---- 311
            ..                                                    .|.:|.|
Zfish  1313 EDVPGTFSRGALGQRARVVSLSQPRVSVKARNSPRGKWGSIRGSGRLSTYNPDVGNRLAGKESPQ 1377

  Fly   312 AKGGGYES-----------------------EDAYKNVEINFLDIHNIHVMRESLRKVKEACFPT 353
            |.||..|:                       :|:::..|:..:::.::..::.|.:|:.:||.|:
Zfish  1378 ANGGPSETYFLRQQRAYLFIIGDKSQLKGGKQDSFQQWEVVPIEVFDVRQVKNSFKKLMKACVPS 1442

  Fly   354 T----DDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLL 414
            :    .:..:...::.:.|:..:..:|..:|.:|:.::. .:||:|...||||.|.|:.:|..||
Zfish  1443 SLSFDANMTFHRCLEESEWMNLLHRVLQVSVLVVELLDN-GSSVMVSLEDGWDVTTQVVSLVQLL 1506

  Fly   415 LDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFE 479
            .||:|||:.||.:|:|||||||||:|..| |........:..:||||||:|.|.|:..||...||
Zfish  1507 SDPYYRTIDGFRLLVEKEWLSFGHRFSHR-GAQTLASQSSGFTPVFLQFLDCVHQIHLQFPMEFE 1570

  Fly   480 FNEHFLITIVDHLYSCRFGTFLCNTEAERV------AEDLKHKTT----SLWTHINSSLDQYLN- 533
            |::::|..:..|..|.||.|||.:::.||:      .|..:.|:|    |:|.:|:.     ||
Zfish  1571 FSQYYLKFLAYHYVSNRFRTFLLDSDYERIELGVLYEEKGERKSTQVCKSVWDYIDR-----LNK 1630

  Fly   534 --PLFPS--FTHGAELVLRPIASVRSVRLWKGLYCRWNPGLCAPQHGCQRTRELLSKQDQL-FKL 593
              |:|.:  |:...|.||:|.:.|.::::| ..|                |.|.||:.... ::|
Zfish  1631 KTPIFYNYMFSPEEEEVLKPYSFVSNLKVW-DFY----------------TEETLSEGPSFDWEL 1678

  Fly   594 VNELRLKSNNRSNSMQTTT 612
            |...:.|....:...|.||
Zfish  1679 VQGRQEKPQEEAGDKQETT 1697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	30/157 (19%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	114/495 (23%)
sbf1	XP_009298445.1	uDENN	1..86	CDD:214824
		DENN	117..327	CDD:280329
		dDENN	381..449	CDD:129037
		SBF2	560..782	CDD:289132
		PH-GRAM_MTMR5	910..1027	CDD:275417	21/94 (22%)
		Myotub-related	1143..1598	CDD:284109	110/456 (24%)
		PH_Sbf1_hMTMR5	1829..1934	CDD:269941
		PH	1834..1934	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590808
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840