DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and mtmr7b

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_005168409.1	Gene:	mtmr7b / 559198	ZFINID:	ZDB-GENE-050913-66	Length:	645	Species:	Danio rerio

Alignment Length:	533	Identity:	209/533 - (39%)
Similarity:	296/533 - (55%)	Gaps:	49/533 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 VIARVEKIGGATSRGENSYG--IEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLF 167
            :::.||::      ..|..|  :.|.||:....|....|:... ..|...|...:.|..| |.||
Zfish    53 LVSNVERL------PTNPSGSPVIIRCKNFIVYRLLIPQEKDC-LDVVASLTRLSRPERY-GELF 109

  Fly   168 AFAHAAANSVNGNGGWD----GWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPK 228
            .|      |.|.|...:    .|...:..||..|:|:|:::|..|..|..|.:||:||:...|||
Zfish   110 CF------SFNPNLDKELREKAWGFMDLKAEFNRMGIPSNLWHVTAANHEYRLCDTYPSELFVPK 168

  Fly   229 AASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQS 293
            :||...:...|:||||.||||||:.:..|.|:|.|.||||.|.|. |:||||..|..||::|..|
Zfish   169 SASPAVIVGSAKFRSRGRLPVLSYFHRDTSASICRSSQPLSGFSA-RSSDDEQMLQAIMKSNPVS 232

  Fly   294 DKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRK---VKEACFPTTD 355
            :.:.::|.||..||:||:|.|.|||:||.|.|:::.|:.|.||||||.|.:|   |.:...|:..
Zfish   233 EFMYVVDTRPKLNAMANRAAGKGYENEDHYTNIKLQFIGIENIHVMRNSQQKLIDVGDMAAPSMA 297

  Fly   356 DSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYR 420
            |..|  .::|:.|||||:.:|...|.|...|.....||:||||||||||||..:::.:||||:||
Zfish   298 DFLW--GLENSGWLKHIKAVLDAGVFIAKAVAEDGVSVLVHCSDGWDRTAQACSVASVLLDPYYR 360

  Fly   421 TVRGFEVLIEKEWLSFGHKFQQRIGH--GDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEH 483
            |::|..|||||:|:||||||..|..|  ||.|    :.|||..||::.|||:.|||..||||||.
Zfish   361 TIKGLMVLIEKDWVSFGHKFSHRYAHLDGDPK----EVSPVMDQFLECVWQLMQQFPCAFEFNER 421

  Fly   484 FLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLR 548
            |||.:...:|||::|.|:.|.:.||....|:.:|.|||.|:..:..:|.|||:.:.....:.|||
Zfish   422 FLIQLHMLIYSCQYGNFIGNCQKERRDLKLQERTHSLWPHLWENRAEYTNPLYRTDHSQTQGVLR 486

  Fly   549 PIASVRSVRLWKGLYCRWNPGLCAPQH--GC---------QRTRELLSKQDQLFKLVNELRLKSN 602
            |:.:....:.|||:|.|....|.:.|.  .|         |...||.:.|::|      .:||..
Zfish   487 PLTTAYCFKFWKGMYGRAERSLSSQQSPADCLNAVREESQQLEEELTAHQERL------AQLKEK 545

  Fly   603 NRSNSMQTTTRLA 615
            ..|...:..:||:
Zfish   546 KTSGERKKISRLS 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	11/55 (20%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	156/333 (47%)
mtmr7b	XP_005168409.1	PH-like	1..102	CDD:302622	11/55 (20%)
mtmr7b	XP_005168409.1	Myotub-related	108..445	CDD:284109	161/349 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850