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Protein Alignment mtm and MTMR8

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_060147.2	Gene:	MTMR8 / 55613	HGNCID:	16825	Length:	704	Species:	Homo sapiens

Alignment Length:	511	Identity:	203/511 - (39%)
Similarity:	293/511 - (57%)	Gaps:	34/511 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VPLGVIARVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQN-----HSRRTVFEKLQANAFPL 160
            :.|..||.|||: ..||.|   ..:.:.||   |.|.||...:     |.......||...|.|.
Human    50 IALHHIATVEKL-PITSLG---CPLTLRCK---NFRVAHFVLDSDLVCHEVYISLLKLSQPALPE 107

  Fly   161 SYSGRLFAFAHAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWA 225
            .    |:||::...:|.....  .||.:.:|:::..|:|:||..|..|..|.:|.||.:||....
Human   108 D----LYAFSYNPKSSKEMRE--SGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIV 166

  Fly   226 VPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEAN 290
            |||:.:...:...::|||:.|:||||::.....|.|.||||||.|.. .|..|||..|..|.:.|
Human   167 VPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFY-TRCVDDELLLEAISQTN 230

  Fly   291 AQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEAC-FPTT 354
            ..|..:.::|.||..||:||:|.|.|||:||.|.|:...|:.|.||||||.||:|:.|.| ..|.
Human   231 PGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTP 295

  Fly   355 DDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHY 419
            ..|::.:.::::.||:||:.|:...:.|...|:....||:||||||||||||:.:::.:||||.|
Human   296 TMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFY 360

  Fly   420 RTVRGFEVLIEKEWLSFGHKFQQRIGH--GDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNE 482
            ||.:|..:||||||:|.||||.||.||  ||:|    :.||:|.||:|.:||:.:||..||||||
Human   361 RTFKGLMILIEKEWISMGHKFSQRCGHLDGDSK----EVSPIFTQFLDCIWQLMEQFPCAFEFNE 421

  Fly   483 HFLITIVDHLYSCRFGTFLCNTEAERVAEDLK--HKTTSLWTHINSSLDQYLNPLFPSFT-HGAE 544
            :||:.|.||::||:||.||.|.:.:|  |||:  .||.|:|..:......:.|||:..|| :|
Human   422 NFLLEIHDHVFSCQFGNFLGNCQKDR--EDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYG-- 482

  Fly   545 LVLRPIASVRSVRLWKGLYCRWNPGLCAPQHGCQRTRELLSKQDQLFKLVNELRLK 600
             ||.|.....:::.|.|:|.|::.||...|...:...|:..::..|...|:||..|
Human   483 -VLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKK 537

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.