Protein Alignment mtm and MTMR10

DIOPT Version :9

• Sequence 1: NP_001285651.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_060232.2
• Gene: MTMR10 / 54893
• HGNCID: 25999
• Length: 777
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 151/658 - (22%)
• Similarity: 254/658 - (38%)
• Gaps: 216/658 - (32%)

  Fly    72 VFGALTITNYRL-------------YFRSLPLRDQEPPVVVDVPLGVIARV---------EKIGG 114
            ::|.|..:|:::             ::|:|.|.:.      ||||..|.::         :|:.|
Human    64 LWGKLICSNFKISFITDDPMPLQKFHYRNLLLGEH------DVPLTCIEQIVTVNDHKRKQKVLG 122

  Fly   115 ATSRGE-NSYGIEIFCKDMRNLRFAHKQQ-------------NHSRRTVFEKLQANAFPLSYSGR 165
            ...:.: |...:.|:|||.|.:||...:.             ::|:.|..:.|    |...|.|:
Human   123 PNQKLKFNPTELIIYCKDFRIVRFRFDESGPESAKKVCLAIAHYSQPTDLQLL----FAFEYVGK 183

  Fly   166 LFAFAHAAANSVN-------------GNGGWDGWAVYEPL--------AELRRLGVPNDMWRATK 209
            .:   |.:||.:|             |||...|.:...||        .|::|.|...  ||...
Human   184 KY---HNSANKINGIPSGDGGGGGGGGNGAGGGSSQKTPLFETYSDWDREIKRTGASG--WRVCS 243

  Fly   210 LNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGK 274
            :||.|.|....|....||.:.:|..|:..:......|:|:..|.:....|.:.
Human   244 INEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHSNGSALVR------------ 296

  Fly   275 RNSDDEAYLSFIMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLD--IHNIH 337
                    ::.|.:         ::..|.....|.|.......:..|.||    :.||  :.||.
Human   297 --------MALIKD---------VLQQRKIDQRICNAITKSHPQRSDVYK----SDLDKTLPNIQ 340

  Fly   338 VMRESLRKVKEAC----FPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCS 398
            .::.:..|:|:.|    |..|:: ||.::::||.||:::|..|..:..:|..:|:...|||:...
Human   341 EVQAAFVKLKQLCVNEPFEETEE-KWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEE 404

  Fly   399 DGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQF 463
            :|.|.:..:.:|..::|||::||:.||:.||:|||:..|::|..|..|  .|.|:.: ||:||.|
Human   405 EGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNH--LKRSEKE-SPLFLLF 466

  Fly   464 IDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKH------------- 515
            :|:.||:.:|:..||||:|.:|..:.|......|||||.|:..:||.:..:.
Human   467 LDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQSTEFAISKNIQLGDEKG 531

  Fly   516 -KTTSLWT-----------------HI-------------------------------------- 524
             |..|:|.                 :|
Human   532 LKFPSVWDWSLQFTAKDRTLFHNPFYIGKSTPCIQNGSVKSFKRTKKSYSSTLRGMPSALKNGII 596

  Fly   525 ---------------------------NSSLDQYLNPLF--PSFTHGAELVLRPIASVRSVRLWK 560
                                       ||..:||....|  |:..||   |:.|..|...::|||
Human   597 SDQELLPRRNSLILKPKPDPAQQTDSQNSDTEQYFREWFSKPANLHG---VILPRVSGTHIKLWK 658

  Fly   561 GLYCRWNP 568
            ..|.||.|
Human   659 LCYFRWVP 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	24/122 (20%)
		Myotub-related	184..509	CDD:399535	93/338 (28%)
MTMR10	NP_060232.2	PH-GRAM_MTMR10	21..195	CDD:270154	31/143 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..217		4/20 (20%)
		Myotub-related	226..507	CDD:284109	89/319 (28%)
		3-PAP	578..705	CDD:289355	18/92 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155610
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840