DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and MTMR12

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001035536.1	Gene:	MTMR12 / 54545	HGNCID:	18191	Length:	747	Species:	Homo sapiens

Alignment Length:	741	Identity:	169/741 - (22%)
Similarity:	270/741 - (36%)	Gaps:	217/741 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LGSKHGGGENGILRDTP--FGYLEGEEDQDQKNDVT-----------------------YV---- 65
            ||....||..|.....|  ..|:..||....:.:||                       ||
Human     2 LGKGVVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLKYVQEDS 66

  Fly    66 CPYRGPVFGALTITNYRLYFRSLPLRDQEPPV----------VV---DVPLGVIARVEKIGGATS 117
            |.:  .|:|.|..|::::.|    |.|.|..:          |:   |:.|..:.::  .|....
Human    67 CQH--GVYGRLVCTDFKIAF----LGDDESALDNDETQFKNKVIGENDITLHCVDQI--YGVFDE 123

  Fly   118 RGENSYG--------IEIFCKDMRNLRFA--HKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHA 172
            :.:..:|        :.|.|||:|..:|.  :.::...:|.|...:.....| ....|||.|::|
Human   124 KKKTLFGQLKKYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAP-KLLKRLFLFSYA 187

  Fly   173 AANSVNGNGGWDGWAVYEP-------------LAELRRLGVPNDMWRATKLNESYAICDSYPAVW 224
            .|...|        .|.:|             ..||.|. ..|..::|..:||.|.:|:..||.:
Human   188 TAAQNN--------TVTDPKNHTVMFDTLKDWCWELERT-KGNMKYKAVSVNEGYKVCERLPAYF 243

  Fly   225 AVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDD---EAYLSFI 286
            .||....::   .|.:|:.. .:|:..|......|.:...:.|       :..||   :...||:
Human   244 VVPTPLPEE---NVQRFQGH-GIPIWCWSCHNGSALLKMSALP-------KEQDDGILQIQKSFL 297

  Fly   287 MEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKV----K 347
                   |.:.....||....:         ::||    :..|||.:..|.......:::    .
Human   298 -------DGIYKTIHRPPYEIV---------KTED----LSSNFLSLQEIQTAYSKFKQLFLIDN 342

  Fly   348 EACFPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSM 412
            ...|..| |.||.:.::::.||..||..|..|:.|.:.:|..:.:|::...:..|....:::|..
Human   343 STEFWDT-DIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQ 406

  Fly   413 LLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNA 477
            |::|||.||..||:.||:|||:..||.|..|..|  .:.:|.:..||||.|:|.|||:..|...|
Human   407 LMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNH--LRQNDKEEVPVFLLFLDCVWQLVHQHPPA 469

  Fly   478 FEFNEHFLITIVDHLYSCRFGTFLCN------TEAERVAEDLKHKTTSLWTHINSSLD-----QY 531
            |||.|.:|..:.|.||...|.||..|      |...|..:|.:.|..:|.|..:.|:.     |.
Human   470 FEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQT 534

  Fly   532 L--NPLFPS-------------FTHGAELVLRPIASVRS-------------------------- 555
            |  |||:..             |.|..:|.| |:...:|
Human   535 LLKNPLYVEKPKLDKGQRKGMRFKHQRQLSL-PLTQSKSSPKRGFFREETDHLIKNLLGKRISKL 598

  Fly   556 -------------------------------------VRLWKGLYCRWNPGLCAPQHGCQRTREL 583
                                                 :::|...|.||.|.......|...|
Human   599 INSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVAT--- 660

  Fly   584 LSKQDQLFKLVNELRLKSNNRSNSMQ 609
            |||..::.:.|..|:.|.:.|.:|.|
Human   661 LSKLLEMMEEVQSLQEKIDERHHSQQ 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	26/151 (17%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	93/350 (27%)
MTMR12	NP_001035536.1	PH-like	26..202	CDD:327399	38/192 (20%)
		PTPc	228..496	CDD:328744	84/301 (28%)
		Interaction with MTM1. /evidence=ECO:0000269\|PubMed:12847286	449..558		35/108 (32%)
		3-PAP	563..686	CDD:315286	19/126 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840