DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and Sbf2

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_006507990.1	Gene:	Sbf2 / 319934	MGIID:	1921831	Length:	1904	Species:	Mus musculus

Alignment Length:	852	Identity:	199/852 - (23%)
Similarity:	300/852 - (35%)	Gaps:	302/852 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LEGEE----------DQDQKNDVT---YVCPYRGPVFGALTITNYRLYFRSLPLRDQ---EPPVV 98
            |.|||          |.|.:.:.|   ...|...|..|||.:|.||:.||..| .||   |..||
Mouse   877 LPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTP-HDQLVGEQTVV 940

  Fly    99 VDVPLGVIARVEKIGGATSRGENSYG---------------------------IEIFCKDMRNLR 136
            ...|:..|.:.:||   |.:.:....                           ::||.|.:...|
Mouse   941 RSFPIASITKEKKI---TMQNQLQQSVQEGLQITSASFQLIKVAFDEEVSPEVVDIFKKQLMKFR 1002

  Fly   137 F----------------------AHKQQNHSRRTVFEKLQANAFPLSYS--GRLFAFAHAAANSV 177
            :                      ..|::|.|.||..:.:...|......  ||.:.........|
Mouse  1003 YPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGAKKAGKMTIGRQYLLKKRTGTIV 1067

  Fly   178 NGNGGWDGW-------------------------AVYEPLAE------LRRLGVPN--------- 202
            .......||                         :..|.|.|      .:|||:..
Mouse  1068 EERVNRPGWNEEDDISVSDDSELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGNSSRSK 1132

  Fly   203 -DMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRC-- 264
             :.:|.|..|..|::|.|||.:..:|:|..|..|.|||:.....||||:.|.|.|:...:.|.
Mouse  1133 PEYFRVTASNRLYSLCRSYPGLLVIPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGG 1197

  Fly   265 --SQPLVGVSGKRNS---------------DDEAYLSFIMEANAQSDKL---------------- 296
              .:.:||:...:||               :.|.||..::.|.....||
Mouse  1198 FHGKGVVGLFKSQNSPQAVSTSSLESSSSIEQEKYLQALLTAVIVHQKLRGSSTLTVRPALALSP 1262

  Fly   297 ----------TI--------MDARPSANAIANKAKG----------------------------- 314
                      |:        :|..|| |:.|....|
Mouse  1263 GTERRSSRMSTVLKQVVPGHLDVNPS-NSFARGVHGYRDKSFTQSNPKSSAKEPVHNQGVWASLR 1326

  Fly   315 -------------------GGYESEDAYKN----------------------------VEINF-- 330
                               .|.:...::.|                            ||..|
Mouse  1327 SSTRLISSPTSFIDVGARLAGKDHSASFSNSTYLQNQLLKRQAALYIFGEKSQLRSSKVEFAFNC 1391

  Fly   331 ----LDIHNIHVMRESLRKVKEACFPTT--DDSK--WQTAIDNTLWLKHIRCILAGAVRIVDKVE 387
                ::.|.|..::.|.:|:..||.|:|  .||:  :..|:.::.|...:..|:..|| :|.:|.
Mouse  1392 EFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAV-VVSEVL 1455

  Fly   388 TMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHS 452
            ...:||.|...:|||.|.|:|:|:.||.||.|||:.||..|:|||||||||||.||.....|...
Mouse  1456 ENGSSVWVCLEEGWDITTQVTSLAQLLSDPFYRTIAGFRTLVEKEWLSFGHKFSQRSSLALNSQG 1520

  Fly   453 DADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDL---- 513
             ...:|:||||:|.|.||..|:...||||.::|..:..|..|.||.|||.:::.||:....
Mouse  1521 -GGFAPIFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDD 1584

  Fly   514 ---KH--KTTSLWTHINSSLDQYLNPLFPSFTHGAELV--LRPIASVRSVRLW---------KGL 562
               ||  |...:|..|:....:  :|:|.::.:....|  |:|..:|.|::.|         .|.
Mouse  1585 KGDKHAKKGVCIWECIDKMHTR--SPIFFNYLYSPVEVEALKPNVNVSSLKKWDYYTEETLSAGP 1647

  Fly   563 YCRWNPGLCAPQH------------GCQRTRELL---------SKQDQLFKLVNELRLKSNNRSN 606
            ...|.  :..|:|            |.|..|:.:         |:.|.|.:|.:|:. |..::.|
Mouse  1648 SYDWM--MLTPKHFPYEESDVAGGAGPQSQRKTVWPCYDDVTCSQPDALTRLFSEIE-KLEHKLN 1709

  Fly   607 SMQTTTR 613
              ||..|
Mouse  1710 --QTPER 1714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	33/156 (21%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	127/504 (25%)
Sbf2	XP_006507990.1	uDENN	1..87	CDD:214824
		DENN	116..298	CDD:366936
		dDENN	352..420	CDD:129037
		SBF2	531..752	CDD:372054
		PH-GRAM_MTMR13	880..998	CDD:275416	29/121 (24%)
		PTP_DSP_cys	1136..1540	CDD:391942	105/406 (26%)
		PH_Sbf1_hMTMR5	1797..1902	CDD:269941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740