DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and Mtmr2

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001101593.1	Gene:	Mtmr2 / 315422	RGDID:	1311865	Length:	643	Species:	Rattus norvegicus

Alignment Length:	647	Identity:	359/647 - (55%)
Similarity:	464/647 - (71%)	Gaps:	45/647 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPSASL----ADKLASKTASSNSLDSSSKSSSLGSKHGGGENGILRDT---------------- 45
            |:.|:|.    |...|::..|.:||.|:|.|.|..|.|....:.|..|:
  Rat     1 MEKSSSCESLGAQLPAARLPSEDSLSSASTSHSENSVHTKSVSAISSDSISTSADNFSPDLRVLR 65

  Fly    46 ----------PFGYLEGEEDQDQKNDVTYVCPYRGPVFGALTITNYRLYFRSLPLRDQEPPVVVD 100
                      | ..|.||..:|...||||:||:.|.|.|.||:|||||||:|:   :::||.|:|
  Rat    66 EANKLAEMEEP-ALLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSM---ERDPPFVLD 126

  Fly   101 VPLGVIARVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGR 165
            ..||||:||||||||:||||||||:|..|||:||||||||.:..:||::||.|...|||:|....
  Rat   127 ASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNGLP 191

  Fly   166 LFAFAHAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAA 230
            ||||.:......|      ||.:|:||.|.||.|:||:.||.||:||.|.:||:|||:.|||...
  Rat   192 LFAFEYKEVFPEN------GWKLYDPLLEYRRQGIPNESWRITKVNERYELCDTYPALLAVPANI 250

  Fly   231 SDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDK 295
            .|:.|:|||.||||.|:|||||::|.:|||:||||||:|||||||:.:||.||..||::||||.|
  Rat   251 PDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHK 315

  Fly   296 LTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQ 360
            :.|.|||||.||:|||||||||||||||:|.|:.||||||||||||||||:||..:|..:::.|.
  Rat   316 IFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWL 380

  Fly   361 TAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGF 425
            :.:::|.||:||:.|||||:||.||||:..||||||||||||||||||:|:||:||.:|||:|||
  Rat   381 SNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGF 445

  Fly   426 EVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVD 490
            |||:|||||||||:||.|:||||..|:|||||||||||||.|||:::||..||||||:|||||:|
  Rat   446 EVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILD 510

  Fly   491 HLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRS 555
            |||||.|||||||:|.:|..|:|..||.|||::|||.|:.:.||||.|:::.   ||.|:||:|.
  Rat   511 HLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLFGSYSNH---VLYPVASMRH 572

  Fly   556 VRLWKGLYCRWNPGLCAPQHGCQRTRELLSKQDQLFKLVNELRLKSNNRSNSMQTTTRLASP 617
            :.||.|.|.||||.:...:....|.:|||:|:.:|.:.|.||:.:.:|||.|  ::.|.:||
  Rat   573 LELWVGYYIRWNPRMKPQEPIHSRYKELLAKRTELQRKVEELQREISNRSTS--SSERASSP 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	62/101 (61%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	222/324 (69%)
Mtmr2	NP_001101593.1	PH-like	73..187	CDD:418428	68/117 (58%)
Mtmr2	NP_001101593.1	Myotub-related	202..528	CDD:399535	223/331 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349536
Domainoid	1	1.000	488	1.000	Domainoid score	I365
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22951
Inparanoid	1	1.050	707	1.000	Inparanoid score	I622
OMA	1	1.010	-	-		QHG58725
OrthoDB	1	1.010	-	-		D319276at33208
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		otm46138
orthoMCL	1	0.900	-	-		OOG6_101490
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770