DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and Mtmr12

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_006232108.1	Gene:	Mtmr12 / 310155	RGDID:	1307902	Length:	748	Species:	Rattus norvegicus

Alignment Length:	687	Identity:	169/687 - (24%)
Similarity:	265/687 - (38%)	Gaps:	184/687 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GSKHGGGENGILRDTPFGYLEGEEDQDQKNDVT------------------------YV----CP 67
            |...|||.....:.:...|:..||....:.:||                        ||    |.
  Rat     5 GGVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEEVTLHLLPGEQLLCEASTVLKYVQEDSCQ 69

  Fly    68 YRGPVFGALTITNYRLYFRSLPLRDQEPPV--------------VVDVPLGVIARVEKIGGATSR 118
            .  .:.|.|..|::|:.|    |.|:...|              |.|:||..:.::  .|....:
  Rat    70 L--GICGRLVCTDFRISF----LGDEGSAVDNGAETHFKNKIIGVNDIPLHCVDQI--YGVFDEK 126

  Fly   119 GENSYG--------IEIFCKDMRNLRFA--HKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAA 173
            .:..:|        :.|.|||:|.|.|.  :.::...:|.|...:.....| ....|||.|::||
  Rat   127 KKPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKEEEVKRIVSGIIHHTQSP-KLLKRLFLFSYAA 190

  Fly   174 ANSVNGNGGWDGWAVYEPLAELRRLGV----PND------------MWRATKLNESYAICDSYPA 222
                         ||:...|:.|...|    |.|            .::...:||.|.:||..||
  Rat   191 -------------AVHGTAADPRNCTVMFDTPKDWCWELERTKGSVKYKTVSVNEGYRVCDRLPA 242

  Fly   223 VWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEA---YLS 284
            .:.||....:|.::|   |:.| .:|:..|......|.:...:.|       :..||.|   ..|
  Rat   243 YFVVPTPLLEDDVKR---FQGR-GIPIWCWSCHNGSALLKMSALP-------KEQDDSALQIQKS 296

  Fly   285 FIMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEA 349
            |:       |.:.....||....:         ::||    :..|||.:..|   :.|..|.|:.
  Rat   297 FL-------DGIYKTIHRPPYEMV---------KTED----LSSNFLSLQEI---QSSYCKFKQL 338

  Fly   350 CFPTTD------DSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLT 408
            ....:.      |.||.:.::::.||..||..|..|:.|::.:|..:.:|::...:..|....|:
  Rat   339 FLIDSSSEFWDTDVKWFSLLESSGWLDIIRRCLKRAIEIIECLEAQNMNVLLLEENASDLCCLLS 403

  Fly   409 ALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQ 473
            :|..:::|.|.||..||:.||:|||:..||.|..|..|  ...||.:..||||.|:|.|||:..|
  Rat   404 SLVQVMMDAHCRTWTGFQSLIQKEWVMGGHSFLDRCNH--LHQSDKEEVPVFLLFLDCVWQLVHQ 466

  Fly   474 FNNAFEFNEHFLITIVDHLYSCRFGTFLCN------TEAERVAEDLKHKTTSLWTHINSSLD--- 529
            ...||||.|.:|..:.|.||...|.||..|      |...|.:.|.:.|..:|.|..:.|:.
  Rat   467 HPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRESLDAQSKPLTLLTVWDWSVQFEP 531

  Fly   530 --QYL--NPLF-------------PSFTHGAELVLRPIASVRSVRLWKGLYCRWNPGLCAPQHGC 577
              |.|  |||:             ..|.|..:|.| |:...:|                :|:.|.
  Rat   532 KAQTLLRNPLYVEKPKLDKGQRKGSRFKHQRQLSL-PLTQSKS----------------SPKRGF 579

  Fly   578 QRTRELLSKQDQLFK-LVNELRLKSNNRSNSMQTTTR 613
            .|     .:.|.|.| |:.:...|..|.|:.:|..:|
  Rat   580 FR-----EETDHLIKNLLGKRISKLINSSDDLQDNSR 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	28/153 (18%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	98/355 (28%)
Mtmr12	XP_006232108.1	PH-like	26..192	CDD:302622	37/187 (20%)
		PTPc	211..497	CDD:304379	90/321 (28%)
		3-PAP	562..686	CDD:289355	16/72 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840