Protein Alignment mtm and Mtmr10

DIOPT Version :10

• Sequence 1: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001094316.1
• Gene: Mtmr10 / 309255
• RGDID: 1305958
• Length: 771
• Species: Rattus norvegicus
• Alignment Length: 655
• Identity: 148/655 - (22%)
• Similarity: 257/655 - (39%)
• Gaps: 214/655 - (32%)

  Fly    72 VFGALTITNYRL-------------YFRSLPLRDQEPPVVVDVPLGVIARV---------EKIGG 114
            ::|.|..:|:::             ::|:|.|.:.      ||||..|.::         :|:.|
  Rat    64 LWGKLICSNFKISFITDDPMPLQKFHYRNLLLGEH------DVPLTCIEQIVTVNDHKRKQKVLG 122

  Fly   115 ATSRGE-NSYGIEIFCKDMRNLRFAHKQQ-------------NHSRRTVFEKLQANAFPLSYSGR 165
            ...:.: |...:.|:|||.|.:||...:.             ::|:.|..:.|    |...|.|:
  Rat   123 PNQKLKFNPTELIIYCKDFRIVRFRFDESGPESAKKVCLAIAHYSQPTDLQLL----FAFEYVGK 183

  Fly   166 LFAFAHAAANSVNG--NGGWDGWA-----------VYEPLA----ELRRLGVPNDMWRATKLNES 213
            .:   |.:||.|||  :||...|:           ::|..:    |.:|.|...  ||...:||.
  Rat   184 KY---HNSANKVNGVSSGGGGVWSGAGSPSSQRTPLFETYSDWDRETKRTGASG--WRVCSINEG 243

  Fly   214 YAICDSYPAVWAVPKAASDDFLRRVA-QFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNS 277
            |.|....|..:.||.:.:|..|:..: .|..| |:|...|.:....|.:.
  Rat   244 YMISTCLPEYFVVPSSLADQDLKIFSPSFVGR-RMPCWCWSHSNGSALVR--------------- 292

  Fly   278 DDEAYLSFIMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLD--IHNIHVMR 340
                 ::.|.:         ::..|.....|.|.......:..|.||    :.||  :.||..::
  Rat   293 -----MALIKD---------VLQQRKIDQRICNAITKSHPQRSDVYK----SDLDKTLPNIQEIQ 339

  Fly   341 ESLRKVKEAC----FPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGW 401
            .:..|:|:.|    |..|:: ||.:::::|.||:::|..|..:..:|..:|:...|||:...:|.
  Rat   340 AAFVKLKQLCVNEPFEETEE-KWLSSLESTRWLEYVRAFLKHSAELVYILESQRLSVVLQEEEGR 403

  Fly   402 DRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDS 466
            |.:..:.:|..:::||::||:.||:.|::|||:..|:.|..|..|  .|.|:.: ||:||.|:|:
  Rat   404 DLSCLVASLVQVMMDPYFRTITGFQSLVQKEWVMAGYPFLDRCNH--LKRSEKE-SPLFLLFLDT 465

  Fly   467 VWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKH--------------KT 517
            .||:.:|:..||||:|.:|..:.|......|||||.|:..:||.:..:.              |.
  Rat   466 TWQLLEQYPAAFEFSETYLAVLCDSTRISLFGTFLFNSPHQRVKQSTEFAISKNIQLGDEKGLKF 530

  Fly   518 TSLWT-----------------HI----------------------------------------- 524
            .|:|.                 :|
  Rat   531 PSVWDWSLQFTAKDRTLFHNPYYIGKSTPCIQNGSRKSFKRTKKSYSSTLRGMPSCLKNGLISDQ 595

  Fly   525 ------------------------NSSLDQYLNPLF--PSFTHGAELVLRPIASVRSVRLWKGLY 563
                                    :|..:||....|  |:..||   ::.|..|...::|||..|
  Rat   596 ELLPRRNSLILKLKPDPPQHGDSQHSGAEQYFKEWFSRPANLHG---IILPRLSGTHIKLWKLCY 657

  Fly   564 CRWNP 568
            .||.|
  Rat   658 FRWVP 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	24/122 (20%)
		Myotub-related	184..509	CDD:461958	91/346 (26%)
Mtmr10	NP_001094316.1	PH-GRAM_MTMR10	21..193	CDD:270154	30/141 (21%)
		PTP-MTMR10	275..468	CDD:350441	58/230 (25%)
		3-PAP	570..701	CDD:463634	16/96 (17%)