Protein Alignment mtm and Mtmr6

DIOPT Version :10

• Sequence 1: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001381640.1
• Gene: Mtmr6 / 305935
• RGDID: 1305378
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 541
• Identity: 195/541 - (36%)
• Similarity: 288/541 - (53%)
• Gaps: 65/541 - (12%)

  Fly   106 IARVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFA 170
            ||.|||:...||    ...:.|.||:.|.:.|...::... ..::..|...:....|.. |:||:
  Rat    53 IASVEKLALTTS----GCPLVIQCKNFRIVHFIVPRERDC-HDIYNSLLQLSKQAKYED-LYAFS 111

  Fly   171 HAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFL 235
            :....  |.....:||.:.:..||..|:||||..|:.:..|..|.:|::||....||:.||...:
  Rat   112 YNPKQ--NDTERLNGWQLIDLAAEYERMGVPNANWQLSDANREYKVCETYPRELYVPRTASRPVI 174

  Fly   236 RRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIMD 300
            ...:.|||:.||||||:....|:|.|.||||||.|.|. |..:||..|..|.:||..:..:.::|
  Rat   175 VGSSNFRSKGRLPVLSYCQQGTEAAICRCSQPLSGFSA-RCLEDEHLLQAISKANPGNRYMYVVD 238

  Fly   301 ARPS--------------------------------------ANAIANKAKGGGYESEDAYKNVE 327
            .||.                                      .||:||:|.|.|||:||.|.|:.
  Rat   239 TRPKLRMQSWWDTQKDIGRIIVRISSKIWNDEKIRESDEKKRLNAMANRAAGKGYENEDNYSNIR 303

  Fly   328 INFLDIHNIHVMRESLRKVKEACFPTTDDSK------WQTAIDNTLWLKHIRCILAGAVRIVDKV 386
            ..|:.|.||||||.||:|:.|     .:.||      :.:.::::.||:||:.:|..|:.:...:
  Rat   304 FQFVGIENIHVMRSSLQKLLE-----VNGSKGLSVNDFYSGLESSGWLRHIKAVLDAAIFLAKAI 363

  Fly   387 ETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGH--GDN 449
            ...:.||:||||||||||:|:.:|..||||.:|||::||.|||||:|:||||||.:|.||  ||.
  Rat   364 VVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTMKGFMVLIEKDWISFGHKFSERCGHLDGDP 428

  Fly   450 KHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLK 514
            |    :.||||.||::.||.:::||..||||||.||:.|.:|::||:||.||.|.:.||....||
  Rat   429 K----EVSPVFTQFLECVWHLTEQFPQAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLK 489

  Fly   515 HKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLYCRWNPGLCAPQHGCQR 579
            .||.|||..:.:...:|||||:.|.:... .||.|..:..:.:.|:.:|.:::..|...|.....
  Rat   490 EKTYSLWPFLLADKKKYLNPLYSSKSQRL-TVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLNI 553

  Fly   580 TRELLSKQDQLFKLVNELRLK 600
            ...:..:..||.:.|.:|..|
  Rat   554 IMNMNEQNKQLEEDVKDLEAK 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	13/52 (25%)
		Myotub-related	184..509	CDD:461958	151/370 (41%)
Mtmr6	NP_001381640.1	PH-GRAM_MTMR6	1..101	CDD:270151	13/52 (25%)
		Interaction with RAB1B. /evidence=ECO:0000250|UniProtKB:Q8VE11	2..141		25/95 (26%)
		PTP_DSP_cys	130..469	CDD:475123	141/348 (41%)