DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and Mtmr3

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_006251364.1	Gene:	Mtmr3 / 305482	RGDID:	1310972	Length:	1207	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	208/598 - (34%)
Similarity:	297/598 - (49%)	Gaps:	108/598 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PFGYLEGEEDQDQKNDVTYVCPYRGPVFGA-LTITNYRLYFRSLPLRDQEPPVVVDVPLGVIARV 109
            ||..|.||..:           |.|....| :.::||||:     ::.:|.  :|:|||.:|..|
  Rat    33 PFLELHGESTE-----------YVGRAEDAIIALSNYRLH-----IKFKES--LVNVPLQLIESV 79

  Fly   110 EKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQ------ANAF-PLSYSGRLF 167
            |        ..:.:.:.:.|||.:.:|        .:...||:.|      .||. |......||
  Rat    80 E--------CRDIFQLHLTCKDCKVIR--------CQFPTFEQCQDWLKRLNNAIRPPGKIEDLF 128

  Fly   168 AFA--------HAAANSVNGNGGWDGWAVYEPLA-ELRRLGVP-NDMWRATKLNESYAICDSYPA 222
            :||        :|:....:|:....|..|..... |:.|:|.. |:.||.:.:||.|.:|.|||.
  Rat   129 SFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQ 193

  Fly   223 VWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIM 287
            ...||...:|..|..||.|||..|:|.:.:.:....|.|.||.||.|...|.||:|||..:..:.
  Rat   194 ELIVPAWITDKELESVAGFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVA 258

  Fly   288 EANA---------------------------------------------QSDKLTIMDARPSANA 307
            :|.|                                             |..||.|:|||..|.|
  Rat   259 KACASDSQSSVGKVSTRNSCRGFPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAA 323

  Fly   308 IANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTLWLKHI 372
            :||:|||||.|..:.|.|.|:.|:.:.|||.:|.|.:.::..|....|...|.:|:::|.||.|:
  Rat   324 VANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHL 388

  Fly   373 RCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFG 437
            ..:|..|:.:|..|:.....|:||||||||||.|:.||:.|||||:||||.||:||:|.|||.||
  Rat   389 SVLLKSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWLDFG 453

  Fly   438 HKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLC 502
            |||..|.|||:|.....:|.|||||::|.|.|:.:||..:|||||.||:.:|.|.|||.||||||
  Rat   454 HKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLC 518

  Fly   503 NTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLY--CR 565
            |...||..:..:.:|.|:|:.:.:....:.|.|:.|   .:|.||.|:..||::.||..:|  |.
  Rat   519 NNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSS---QSEAVLYPVCHVRNLMLWSAVYLPCP 580

  Fly   566 WNPGL-----CAP 573
             :|..     |||
  Rat   581 -SPSTPTDDSCAP 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	24/109 (22%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	151/371 (41%)
Mtmr3	XP_006251364.1	PH-GRAM_MTMR3	23..116	CDD:270149	27/116 (23%)
		PTP-MTMR3	169..485	CDD:350434	124/315 (39%)
		FYVE_MTMR3	1115..1184	CDD:277271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750