DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and Mtm1

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_038967748.1	Gene:	Mtm1 / 288762	RGDID:	1304582	Length:	603	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	324/611 - (53%)
Similarity:	422/611 - (69%)	Gaps:	25/611 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ASSNSLDSSSKSSSLGSKHGGGENGILRDTPFG--YLEGEEDQDQKNDVTYVCPYRGPVFGALTI 78
            |||::.|..:......|.....::|:.:|....  .|.||.....| :|.|:||:.|||.|.|.|
  Rat     2 ASSSASDCDAHPVERESMRKVSQDGVRQDMSKSGPRLPGESAITDK-EVIYICPFSGPVKGRLYI 65

  Fly    79 TNYRLYFRSLPLRDQEPPVVVDVPLGVIARVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQN 143
            ||||||.|||. .|..|  ::|||||||:|:||:||.|||||||||::|.|||:||||||.||:.
  Rat    66 TNYRLYLRSLE-TDLAP--ILDVPLGVISRIEKMGGVTSRGENSYGLDITCKDLRNLRFALKQEG 127

  Fly   144 HSRRTVFEKLQANAFPLSYSGRLFAFAHAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRAT 208
            ||||.:|:.|..:||||:|:..||||.:.....|      ||||:|.|:.|.||.|:|:..||.:
  Rat   128 HSRRDIFDVLTRHAFPLAYNLPLFAFVNEEKFKV------DGWAIYNPVEEYRRQGLPDRHWRIS 186

  Fly   209 KLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSG 273
            .:|:.|.:||:|||:..||..||||.|||||.||||.|:|||||::|..:|.|.|||||||||.|
  Rat   187 FVNQRYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENRAAIMRCSQPLVGVGG 251

  Fly   274 KRNSDDEAYLSFIMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHV 338
            ||:.|||.||..|.|.|.|:.||||.||||..||:||||.|||||.||||.:.|::|||||||||
  Rat   252 KRSRDDERYLDIIRETNKQTSKLTIYDARPGVNAVANKATGGGYEGEDAYPHAELSFLDIHNIHV 316

  Fly   339 MRESLRKVKEACFPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDR 403
            ||||||:|::..:|..:::.|.:::::|.||:||:.:|.||:|:.|||.:..:||:|||||||||
  Rat   317 MRESLRRVRDIVYPHVEEAHWLSSLESTHWLEHIKLLLTGAIRVADKVASGLSSVLVHCSDGWDR 381

  Fly   404 TAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVW 468
            |||||.|:||:||..||::.|||:|::|||:||||||..||||||..|:||||||:||||||.||
  Rat   382 TAQLTTLAMLMLDGFYRSIEGFEILVQKEWISFGHKFSSRIGHGDKNHADADRSPIFLQFIDCVW 446

  Fly   469 QVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLN 533
            |:::||..||||||.||:.|:||||||||||||.|.||.|..:.|..:|.|:|:.|||:.|::.|
  Rat   447 QMTKQFPTAFEFNECFLVAILDHLYSCRFGTFLLNCEAARERQRLAERTVSVWSLINSNKDEFTN 511

  Fly   534 PLFPSFTHGAELVLRPIASVRSVRLWKGLYCRWNPGLCAPQ-HGC-QRTRELLSKQDQLFKLVNE 596
            |.   :...:..|:.|:.|||.:.||...|.||||.:...| |.. ||..|||:.:|...|.:.|
  Rat   512 PF---YARESNRVIYPVTSVRHLELWVNYYIRWNPRIRQQQPHPMEQRYNELLALRDDYIKKLEE 573

  Fly   597 LRL--------KSNNRSNSMQTTTRL 614
            |:|        .|...|.|.|...|:
  Rat   574 LQLATPTKLTDSSTPPSGSAQIAPRM 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	62/101 (61%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	203/324 (63%)
Mtm1	XP_038967748.1	PH-like	44..143	CDD:418428	62/102 (61%)
Mtm1	XP_038967748.1	Myotub-related	162..489	CDD:399535	204/326 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349524
Domainoid	1	1.000	488	1.000	Domainoid score	I365
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	707	1.000	Inparanoid score	I622
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D319276at33208
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		otm46138
orthoMCL	1	0.900	-	-		OOG6_101490
Panther	1	1.100	-	-	LDO	PTHR10807
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760