DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and Mtmr12

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_766546.1	Gene:	Mtmr12 / 268783	MGIID:	2443034	Length:	747	Species:	Mus musculus

Alignment Length:	686	Identity:	167/686 - (24%)
Similarity:	265/686 - (38%)	Gaps:	183/686 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GSKHGGGENGILRDTPFGYLEGEEDQDQKNDVT-----------------------YV----CPY 68
            |...|||.....:.:...|:..||....:.:||                       ||    | .
Mouse     5 GGVGGGGGTKAPKPSFVSYVRPEEIHTDEKEVTEKEVTLHLLPGEQLLCEASTVLKYVQEDSC-Q 68

  Fly    69 RGPVFGALTITNYRLYFRSLPLRDQEPPV--------------VVDVPLGVIARVEKIGGATSRG 119
            || |:|.|..|::::.|    |.|::..:              |.||||..:.::  .|....:.
Mouse    69 RG-VYGRLVCTDFKISF----LGDEDSALDNGGEAQFKNKIIGVNDVPLHCVDQI--YGVFDEKK 126

  Fly   120 ENSYG--------IEIFCKDMRNLRFA--HKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAAA 174
            :..:|        :.|.|||:|.|.|.  :.::...:|.|...:.....| ....|||.|::||
Mouse   127 KPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKEEEVKRIVSGIIHHTQSP-KLLKRLFLFSYAA- 189

  Fly   175 NSVNGNGGWDGWAVYEPLAELRRLGV----PND------------MWRATKLNESYAICDSYPAV 223
                        ||:....:.|...|    |.|            .:|...:||.|.:.|..||.
Mouse   190 ------------AVHGTATDSRNCTVMFDTPKDWCWELERTKGSVKYRTVSVNEGYRVSDRLPAY 242

  Fly   224 WAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDD---EAYLSF 285
            :.||....:|.:||   |:.. .:|:..|......|.:...:.|       :..||   :...||
Mouse   243 FVVPTPLPEDDVRR---FQGH-GIPIWCWSCHNGSALLKMSALP-------KEQDDGALQVQKSF 296

  Fly   286 IMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEAC 350
            :       |.:.....||....:         ::||    :..|||.:..|   :.:..|.|:..
Mouse   297 L-------DGIYKTIHRPPYEMV---------KTED----LSSNFLSLQEI---QSAYCKFKQLF 338

  Fly   351 FPTTD------DSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTA 409
            .....      |.||.:.::::.||..||..|..|:.|.:.:|..:.:|::...:..|....|::
Mouse   339 LIDNSSEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECLEAQNVNVLLLEENASDLCCLLSS 403

  Fly   410 LSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQF 474
            |..:::|.|.||..||:.||:|||:..||.|..|..|  ...||.:..|:||.|:|.|||:..|:
Mouse   404 LVQVMMDAHCRTRTGFQSLIQKEWVMGGHSFLDRCNH--LHQSDKEEVPIFLLFLDCVWQLVHQY 466

  Fly   475 NNAFEFNEHFLITIVDHLYSCRFGTFLCN------TEAERVAEDLKHKTTSLWTHINSSLD---- 529
            ..||||.|.:|..:.|.||...|.||..|      |...|...|.:.|..:|.|..:.|:.
Mouse   467 PPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRENLDAQSKPLTLLTVWDWSVQFEPK 531

  Fly   530 -QYL--NPLF-------------PSFTHGAELVLRPIASVRSVRLWKGLYCRWNPGLCAPQHGCQ 578
             |.|  |||:             ..|.|..:|.| |:...:|                :|:.|..
Mouse   532 AQTLLRNPLYVEKPKLDRGQQKGSRFKHQRQLSL-PLTQSKS----------------SPKRGFF 579

  Fly   579 RTRELLSKQDQLFK-LVNELRLKSNNRSNSMQTTTR 613
            |     .:.|.|.| |:.:...|..|.|:.:|.::|
Mouse   580 R-----EETDHLIKNLLGKRISKLINSSDDLQDSSR 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	30/152 (20%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	94/355 (26%)
Mtmr12	NP_766546.1	PH-like	26..204	CDD:302622	42/199 (21%)
		PTPc	210..496	CDD:304379	87/321 (27%)
		Interaction with MTM1. /evidence=ECO:0000250	449..558		34/108 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..575		6/43 (14%)
		3-PAP	561..685	CDD:289355	16/72 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846043
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840