Protein Alignment mtm and MTMR11

DIOPT Version :10

• Sequence 1: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001139334.1
• Gene: MTMR11 / 10903
• HGNCID: 24307
• Length: 709
• Species: Homo sapiens
• Alignment Length: 721
• Identity: 173/721 - (23%)
• Similarity: 255/721 - (35%)
• Gaps: 240/721 - (33%)

  Fly    23 SSSKSSSLGSKHGGGENGILRDTPFGYLEGEEDQDQKNDVTYVCPYRGPVFGALTITNYRLYFRS 87
            |...||.|.|:...||. ||...| |..:|.|.:               :.|.|..||:|:.|:.
Human    34 SRQPSSCLASRCLPGEQ-ILAWAP-GVRKGLEPE---------------LSGTLICTNFRVTFQP 81

  Fly    88 LPLR-DQEPPV--VVDVPLGVIARVEKIGGATSRGENSYG---------IEIFCKDMRNLRFAHK 140
            ...: :|:.|:  ..|..|..|.|:|.:.|.:.......|         |.|..:|.|.||..
Human    82 CGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRPGSLHKFIPEEILIHGRDFRLLRVG-- 144

  Fly   141 QQNHSRRTVFEK--LQANAFPLSYSGRLFAFAHAAANSV------------NGNGG--------- 182
                     ||.  |:..||.::.:   ...|.|.:|..            .|:|.
Human   145 ---------FEAGGLEPQAFQVTMA---IVQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPLME 197

  Fly   183 -WDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCR 246
             .:.|       |..|.......||.:.:||.:.:..|.|..:.||....|..:||......:.|
Human   198 TAEDW-------ETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGR 255

  Fly   247 LPVLSWMNPRTQATITRC------SQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTI--MDARP 303
            .|.|||.:| ..:.:.||      |.|        |.:|...:..:::| ..||.:.:  ||..|
Human   256 GPRLSWHHP-GGSDLLRCGGFYTASDP--------NKEDIRAVELMLQA-GHSDVVLVDTMDELP 310

  Fly   304 SANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTD--DSKWQTAIDNT 366
            |                         ..|:...|:      :::..|.|.:.  :.||.:|::.|
Human   311 S-------------------------LADVQLAHL------RLRALCLPDSSVAEDKWLSALEGT 344

  Fly   367 LWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEK 431
            .||.::|..|..|..|...|.:...||::......|....|::|..||..|..||:.||:.|:::
Human   345 RWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQR 409

  Fly   432 EWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCR 496
            ||::.||.|..|:| |.....:|   ||||.|:|.|||:.|||...|||:|.||:.:.|.:....
Human   410 EWVAAGHPFLTRLG-GTGASEEA---PVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPD 470

  Fly   497 FGTFLCNTEAERVAE--DLKHKT-------------------TSLW----THINSSLDQYLNPLF 536
            ..|||.||..||..:  .|...|                   .|:|    .:.|:.:.|:.||.:
Human   471 TLTFLRNTPWERGKQSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGY 535

  Fly   537 ----------------------PS----FTHGAELVL---------------------RPIASVR 554
                                  ||    |:.||...|                     ||..|..
Human   536 DPEHCPDSWLPRPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSE 600

  Fly   555 S------------------------------VRLWKGLYCRWNP----GLCAP-----QHGCQRT 580
            |                              :|||:..|.|..|    ||.||     |......
Human   601 SLADQEWGLPSHWGACPLPPGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQDELSHL 665

  Fly   581 RELLSK 586
            :|||.|
Human   666 QELLRK 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	25/115 (22%)
		Myotub-related	184..509	CDD:461958	95/334 (28%)
MTMR11	NP_001139334.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		1/4 (25%)
		PH-like	46..160	CDD:473070	34/141 (24%)
		PTP_DSP_cys	254..444	CDD:475123	64/234 (27%)
		3-PAP	551..678	CDD:463634	25/121 (21%)