DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtm and mtmr11

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001313370.1	Gene:	mtmr11 / 101882209	ZFINID:	ZDB-GENE-130530-726	Length:	814	Species:	Danio rerio

Alignment Length:	526	Identity:	129/526 - (24%)
Similarity:	222/526 - (42%)	Gaps:	117/526 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 GPVFGALTITNYRLYFRSLPLRDQEP-----PVVV---DVPLGVIARVEKIGGATSR-------- 118
            |.:.|.|..|::|:.|  :|...|:|     ||::   ||.|..|.:|..:|.:.::
Zfish    64 GWLSGTLFCTHFRVAF--VPQDSQKPDDNADPVLLGDHDVALASIEKVVAVGPSRTKLVTPTCSL 126

  Fly   119 ---GENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKL--QANAFPLSYS----------GRLFA 168
               .|.   :.::|:|:|.|.|           :|::|  ...|..::|:          |.:.:
Zfish   127 KFTPEE---LVLYCRDLRVLCF-----------LFDRLTPDTQAVEITYTIAKTYQPLKPGTILS 177

  Fly   169 FAHAAANSVN-----GNGGWD----------GWAVYEPLAELRRLGVPNDMWRATKLNESYAICD 218
            |.:||..|:.     .|...|          ||.     .||.|.|...  ||.:.:|:.:.:..
Zfish   178 FQNAALGSIEMKQFLSNRRRDPSMNWLECSLGWE-----QELERTGASG--WRVSSVNDRFEMST 235

  Fly   219 SYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNS-----D 278
            |.|....||:...|..|::.....:..|:|...|.:||        ...|:.::..:|:     |
Zfish   236 SLPRFNVVPQRVLDTELKKTFAHFNEGRIPRWCWRHPR--------GSDLLRMASFQNNIYHEKD 292

  Fly   279 DEAYLSFIMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESL 343
            |...|..::....|  ...|:|......:.|                      ||...|....:|
Zfish   293 DIRNLELVLFGGQQ--LCVIVDLGEEMPSPA----------------------DIQLAHTRLRTL 333

  Fly   344 RKVKEACFPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLT 408
            .....:...:..|.||.:.:::|.||.:.||.|..|..:...:.....:||:...:..|....:.
Zfish   334 CLGDISSSVSVPDDKWLSTLESTRWLDYTRCCLRKAAEVCCLLRAGHMTVVLQEPEDRDMNCVVC 398

  Fly   409 ALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQ 473
            :|..::.|||.|||.||:.|::|||::.||||..||.:  ::.||.:.:||||.|:|.|||:..|
Zfish   399 SLVQVMCDPHCRTVAGFQGLVQKEWITAGHKFLSRINY--HRESDKEEAPVFLLFLDCVWQLWAQ 461

  Fly   474 FNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHINSSLD-------QY 531
            :...|:..|.:|:.:.|.::...|.:||.|::.||.... :|...| :|.:|...|       :.
Zfish   462 YPARFQLTEDYLLALHDSVHLPLFSSFLANSQRERCRRS-QHLPQS-YTPVNGLRDVPMSVPEEP 524

  Fly   532 LNPLFP 537
            ::|.||
Zfish   525 VDPPFP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	26/109 (24%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	87/339 (26%)
mtmr11	NP_001313370.1	PH-GRAM_MTMR11	41..162	CDD:275433	26/113 (23%)
		PTPc	210..495	CDD:304379	84/325 (26%)
		3-PAP	578..703	CDD:289355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590813
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840