DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and mtmr2

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_002935623.3	Gene:	mtmr2 / 100494494	XenbaseID:	XB-GENE-6044385	Length:	570	Species:	Xenopus tropicalis

Alignment Length:	569	Identity:	329/569 - (57%)
Similarity:	427/569 - (75%)	Gaps:	16/569 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LEGEEDQDQKNDVTYVCPYRGPVFGALTITNYRLYFRSLPLRDQEPPVVVDVPLGVIARVEKIGG 114
            |.||..:|...||||:||:.|...|:.|:||||||||||. ||:.  :|:|.|||:|:|:|||||
Frog     7 LPGESVKDIAKDVTYICPFSGAYRGSFTVTNYRLYFRSLE-RDRH--LVLDAPLGIISRIEKIGG 68

  Fly   115 ATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAAANSVNG 179
            |.|||||..||||.||||||:|||:||...:|::|||.|...||||:|...||||.:......|
Frog    69 AASRGENPNGIEIVCKDMRNIRFAYKQDLRTRKSVFENLVKFAFPLNYGLPLFAFEYKEVFPEN- 132

  Fly   180 NGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSR 244
                 ||.||:|:.|.||.|:||:.||.|::||.|.:||:|||...||...|||.||::|.||::
Frog   133 -----GWKVYDPIQEYRRQGIPNESWRITRVNERYELCDTYPACLVVPANISDDELRKIAAFRAQ 192

  Fly   245 CRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIMDARPSANAIA 309
            .|:|||||::|.:||.||||||||.||:|||:.:||.||..||:|||||.|:.|.|||||.||:|
Frog   193 DRIPVLSWIHPESQAAITRCSQPLPGVNGKRSKEDEKYLQSIMDANAQSHKVFIFDARPSVNAVA 257

  Fly   310 NKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTLWLKHIRC 374
            ||||||||||||||:|.|:.|||||||||||||.||:||..:|:..::.|.:.:::|.||:||:.
Frog   258 NKAKGGGYESEDAYQNAELVFLDIHNIHVMRESQRKLKEISYPSIQEANWLSNLESTHWLEHIKL 322

  Fly   375 ILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHK 439
            |||||:||.||||:..||||||||||||||.|||:|:|::||.:|||:||||||:||||:||||:
Frog   323 ILAGALRIADKVESGKTSVVVHCSDGWDRTPQLTSLAMIMLDGYYRTIRGFEVLVEKEWVSFGHR 387

  Fly   440 FQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNT 504
            |.||.||||..|:||||||:||||||.|||:::||.|||||||||||.|:||||||.|||||||.
Frog   388 FYQRTGHGDKNHADADRSPMFLQFIDCVWQMTRQFPNAFEFNEHFLIIILDHLYSCLFGTFLCNC 452

  Fly   505 EAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSF-THGAELVLRPIASVRSVRLWKGLYCRWNP 568
            |.:::.|.:..::.|||:.|||.|:.::|||:.:: :|    ||.|:.|.|::.||.|.|.||||
Frog   453 ELQKLKEGVVEESVSLWSFINSQLEDFINPLYVNYSSH----VLYPVTSTRNLELWAGYYIRWNP 513

  Fly   569 GLCAPQHGCQRTRELLSKQDQLFKLVNELRLKSNNRSNSMQTTTRLASP 617
            ....|.....|.:.||:|:.:|.|.:.||:.:.:|||.|  ::.|.:||
Frog   514 RTRPPGAINSRYKVLLAKRAELQKRLEELQREISNRSTS--SSDRGSSP 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	61/101 (60%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	215/324 (66%)
mtmr2	XP_002935623.3	PH-like	1..115	CDD:418428	66/110 (60%)
mtmr2	XP_002935623.3	Myotub-related	130..455	CDD:399535	216/330 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	475	1.000	Domainoid score	I434
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H22951
Inparanoid	1	1.050	667	1.000	Inparanoid score	I751
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D319276at33208
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		otm49224
Panther	1	1.100	-	-	O	PTHR10807
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160