DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtm and sbf1

DIOPT Version :9

Sequence 1:	NP_001285651.1	Gene:	mtm / 33845	FlyBaseID:	FBgn0025742	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_012813917.1	Gene:	sbf1 / 100125154	XenbaseID:	XB-GENE-1013544	Length:	1923	Species:	Xenopus tropicalis

Alignment Length:	785	Identity:	171/785 - (21%)
Similarity:	287/785 - (36%)	Gaps:	291/785 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LEGEE-------------DQDQKNDVTYVCPYRGPVFGALTITNYRLYFRSLPLRD--QEPPVVV 99
            |.|||             .:::.:.|:...|...|..|||.:|:||..|:..|:..  .|..||.
Frog   880 LAGEEMVMDGLRVYLLPDGREEASGVSLGGPPLLPAEGALFLTSYRCIFKGTPVDSLVAEQSVVR 944

  Fly   100 DVPLGVIARVEKIG------------------------GATSRGENSYGIEIFCKDMRNLRF--- 137
            ..|:..:.:.:||.                        .|......|...|:|.|::..|||
Frog   945 SFPIASLTKEKKINVTVQLDQYLQEALQLRSCTFQLLKVAFDEDVPSEASELFRKNLHKLRFPQD 1009

  Fly   138 --------AHKQQNHSRRT----------------VFEKLQANAFPLSYSGRLFAFAHAAANSVN 178
                    |.....||.:|                ||:...|.:|.|   ||.:.....:.|.|.
Frog  1010 VLGTFPLTAGLTVQHSTQTRAKDKNPSLNPLHVTDVFQSHVAMSFSL---GRFYKDTTLSKNLVK 1071

  Fly   179 ----------------GNGGWDGWAVYEPL----------------------------------- 192
                            ....||.......|
Frog  1072 NAKKTIGRQYVTRRKYSPPSWDHRGSQNSLEQQSDDISLSEEMERNTLTTSTLKAPEKQTIGNVA 1136

  Fly   193 -----AELRRLGV----------PNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFR 242
                 .:.:|:|:          .|:.:|.:.:|..||:|:|||.:..||.:..|:.|:::::..
Frog  1137 ERACCRDYQRMGLGTLSNSLQRSKNEPFRISTVNRMYAVCNSYPGLLIVPHSIQDNTLQKISRCY 1201

  Fly   243 SRCRLPVLSWMNPRTQATITRC----SQPLVGVSGKRNS-------------DDEAYLSFI---M 287
            .:.|.||:.|.:||::|.:.|.    .:.:||:....|:             :.|.||..:   |
Frog  1202 RQNRFPVVCWRSPRSKAVLLRSGGLHGKGVVGLFKSPNTTAVGQSQTDSTSLEQEKYLQAVVNCM 1266

  Fly   288 EANAQSDKLTIMDARPSAN---------------------------------------------- 306
            ...|:......:.|.|||:
Frog  1267 PRFAEMSGRNTLSAFPSAHLYDSPDKRQPKLGSLMKQVIGGKEDNRGGYSVRGIKHPAVRRGYIE 1331

  Fly   307 ------------------------------AIANKAKGGGYES---------------------- 319
                                          .:.:...||..||
Frog  1332 QGKWGSMRGSGRLSAYAMNSDVGTRLAGRELVTHNQNGGPSESALTPRRAALYIIGDKSQLKGVK 1396

  Fly   320 EDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDS----KWQTAIDNTLWLKHIRCILAGAV 380
            :|..:..|:..:::.::..::.|.:|:.:||.|:...|    .:...::::.||..:..:|..:|
Frog  1397 QDPLQQWELVPIELFDVRQVKGSFKKLMKACVPSAPSSDPSQSYLRTLEDSEWLVQLHKLLQVSV 1461

  Fly   381 RIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIG 445
            .:|:.::: .:||:|...||||.|.|:.:|..||.||:|||:.||.:|:|||||||||:|..|
Frog  1462 LVVELLDS-GSSVLVGLEDGWDLTTQVVSLVQLLSDPYYRTIEGFRLLVEKEWLSFGHRFSHR-- 1523

  Fly   446 HGDNKHSDADRS----PVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEA 506
               ..|:.|.:|    ||||||:|.|.||..||.:.|||::::|..:..|..|.||.|||.:::.
Frog  1524 ---GAHTAASQSNGFTPVFLQFLDCVHQVHLQFPSEFEFSQYYLKFLAYHYVSNRFRTFLLDSDC 1585

  Fly   507 ERVAEDLKHK----------TTSLW-----THINSSLDQYLNPLFPSFTHGAE--LVLRPIASVR 554
            ||:.:.:.::          ..|:|     .|..|       |:|.::....|  .||||.:||.
Frog  1586 ERIEKGVLYEEKGDRRSPQVCRSVWECMERLHKKS-------PVFYNYMFSPEDGEVLRPFSSVW 1643

  Fly   555 SVRLW 559
            .:|:|
Frog  1644 GLRVW 1648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtm	NP_001285651.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	32/154 (21%)
mtm	NP_001285651.1	Myotub-related	184..509	CDD:399535	112/500 (22%)
sbf1	XP_012813917.1	uDENN	1..86	CDD:214824
		DENN	117..306	CDD:214823
		dDENN	360..428	CDD:129037
		SBF2	538..754	CDD:289132
		PH-GRAM_MTMR5	883..1001	CDD:275417	24/117 (21%)
		Myotub-related	1142..1586	CDD:284109	109/449 (24%)
		PH_Sbf1_hMTMR5	1816..1921	CDD:269941
		PH	1820..1921	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910