DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9109 and B3GLCT

DIOPT Version :9

Sequence 1:	NP_001285650.1	Gene:	CG9109 / 33844	FlyBaseID:	FBgn0031765	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_919299.3	Gene:	B3GLCT / 145173	HGNCID:	20207	Length:	498	Species:	Homo sapiens

Alignment Length:	472	Identity:	168/472 - (35%)
Similarity:	241/472 - (51%)	Gaps:	68/472 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 HPQQARSDCLALSHNVLEQQRALELAGIFPEDFVLKVHVMHELFNSWTMLDALPHLRAQARVLGA 100
            |.::|..    |..::|:|  |.:|....|.  ||.:|.:.:...:||:|..|||...   ....
Human    70 HAKRAEQ----LKKSILKQ--AADLTQELPS--VLLLHQLAKQEGAWTILPLLPHFSV---TYSR 123

  Fly   101 RTEWIIWCQHNTRVSSLRGLLEQLRRQNPRELAFYGHALYDAEATIIHHFSNYKDPQRFPYPMLS 165
            .:.||.:|:..||: .:..|||.|||.:|.:..|.|.||:|.|||||||::..::|..|.||..:
Human   124 NSSWIFFCEEETRI-QIPKLLETLRRYDPSKEWFLGKALHDEEATIIHHYAFSENPTVFKYPDFA 187

  Fly   166 AGVVFTGALLRRLADLVAPSGQNITVHSDFSIDASHELARFIFDN-----VSPDPHISTPISGGI 225
            ||...:..|:.:|...:    ::.::.|||:||..||:|.:|:|.     ::|.|...|
Human   188 AGWALSIPLVNKLTKRL----KSESLKSDFTIDLKHEIALYIWDKGGGPPLTPVPEFCT------ 242

  Fly   226 LLKSASYICSTP--TSVPNRKLPCLLHAQPEEPLTLGQRRNGCEHTTGSHIYFAIKTCAKFHKER 288
              ....:.|:|.  :.:|..:.|                      .....|:.|:|||.|||.:|
Human   243 --NDVDFYCATTFHSFLPLCRKP----------------------VKKKDIFVAVKTCKKFHGDR 283

  Fly   289 IPIIERTWAADARNRRYYSDVADVGIPAIGTGIPNVQTGHCAKTMAILQLSLKDIGKQLDIRWLM 353
            |||:::||.:.|....||||..:..||.:..||||...|||.||.|||:..|.  ..|....||:
Human   284 IPIVKQTWESQASLIEYYSDYTENSIPTVDLGIPNTDRGHCGKTFAILERFLN--RSQDKTAWLV 346

  Fly   354 LVDDDTLLSLHLIHTHLPTSVPRVSALLCRHNATELVYLGQRYGYRLHAPDGFNYHTGGAGIVLS 418
            :||||||:           |:.|:..||..:::.|.|:||:||||.| ...|::|.|||.|:|.|
Human   347 IVDDDTLI-----------SISRLQHLLSCYDSGEPVFLGERYGYGL-GTGGYSYITGGGGMVFS 399

  Fly   419 LPLV-RLIVQRCSCPSASAPDDMILGYCLQALGVPAIHVAGMHQARPQDYAGELLQLHAPLTFHK 482
            ...| ||:..:|.|.|..|||||:||.|...||:|..|....|||||.||..:.|....|::|||
Human   400 REAVRRLLASKCRCYSNDAPDDMVLGMCFSGLGIPVTHSPLFHQARPVDYPKDYLSHQVPISFHK 464

  Fly   483 FWNTDPEHTYRRWLGGS 499
            .||.||...|..||..|
Human   465 HWNIDPVKVYFTWLAPS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9109	NP_001285650.1	Fringe	269..486	CDD:190308	95/217 (44%)
B3GLCT	NP_919299.3	Galactosyl_T	264..467	CDD:304462	94/216 (44%)
B3GLCT	NP_919299.3	Prevents secretion from ER	495..498
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147856
Domainoid	1	1.000	185	1.000	Domainoid score	I3402
eggNOG	1	0.900	-	-		E1_KOG2246
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14978
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3047
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49304
OrthoDB	1	1.010	-	-		D398760at33208
OrthoFinder	1	1.000	-	-		FOG0006008
OrthoInspector	1	1.000	-	-		oto89503
orthoMCL	1	0.900	-	-		OOG6_107040
Panther	1	1.100	-	-	LDO	PTHR10811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3440
SonicParanoid	1	1.000	-	-		X4307
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800