DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and LHX2

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens

Alignment Length:	228	Identity:	62/228 - (27%)
Similarity:	86/228 - (37%)	Gaps:	66/228 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 HNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQL--LDIAPTSPAAAAAATSQNGAHGHGG-- 278
            |.....|.:...||....||         |:.|...  .|:|..:.|||||.::..||.|...
Human   155 HFGMKDSLVYCRLHFEALLQ---------GEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLG 210

  Fly   279 ---GNGQGNASAGSNGKRK--------RSWSRAVFSN------LQR----------KGLEIQFQQ 316
               .||.|....|...|||        .:::.|:..|      |.|          |.:...|:.
Human   211 LPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKH 275

  Fly   317 QKYIT---------KPDR---RKLAARLNLTDAQVKVWFQNRRMKWRHT---RENLKSGQEKQPS 366
            .:..|         .||.   ::||.:..||...::|||||.|.|:|..   :||  :|.:|...
Human   276 HQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQEN--TGVDKSTD 338

  Fly   367 AVPESGGVFKTSTPSGDGTPQEALDYSSDSCSS 399
            |      ..:|.||||   |...|..:|.|.||
Human   339 A------ALQTGTPSG---PASELSNASLSPSS 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	20/80 (25%)
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	3/13 (23%)
		COG5576	<247..378	CDD:227863	36/127 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		3/19 (16%)
		Homeobox	270..323	CDD:395001	15/52 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		16/46 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910