DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and Zfhx4

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001355600.1	Gene:	Zfhx4 / 80892	MGIID:	2137668	Length:	3607	Species:	Mus musculus

Alignment Length:	436	Identity:	97/436 - (22%)
Similarity:	145/436 - (33%)	Gaps:	143/436 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ESCASTTIVSTSPTSATSTTKVKLSFSVDRLLGS---EPEES--------HRQSSSSPS----TK 98
            ::..||..:..|..|.|||.          |:.|   |||::        .:...|.||    ||
Mouse  2368 DTAKSTATLVASSGSGTSTP----------LIPSPKPEPEKNSPKTEYPGEKTKQSDPSLPQGTK 2422

  Fly    99 SCCDGSILAC-----CSFPHCFSQANAESRRFGHATLPP----TFTPTSSHTYPFVGLDKLFPGP 154
            | ...|:|..     .|.|...:|...:.:..|.   ||    |..|:|........|....|..
Mouse  2423 S-APSSVLTSSEPQQASIPQPPTQPPKQPQLIGR---PPSASQTPIPSSPLQISMTSLQNSLPPQ 2483

  Fly   155 YMDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQHQKQQHQQHHHHQH-HPKHLHQQHKPP-- 216
            .:.|          ..:.....:|||   .|.:.|||   .|.....:|. |...|.:....|
Mouse  2484 LLQY----------PCDQCTIAFPTL---ELWKEHQH---MHFLAAQNQFLHSPFLERPMDMPYM 2532

  Fly   217 ---PHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQ-------- 270
               |:|......||.  .|||.:             |.|......|:||:.||:..:
Mouse  2533 IFDPNNPLMTGQLLG--SSLTQM-------------PPQTSTAHTTAPASVAASLKRKLEDKEDN 2582

  Fly   271 NGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRRKL---AARL 332
            |.:...||.:|:..    ...||.|       :.:..:.|||.:::....:.|.|:.|   |..:
Mouse  2583 NCSEKEGGNSGEDQ----HRDKRLR-------TTITPEQLEILYEKYLLDSNPTRKMLDHIAREV 2636

  Fly   333 NLTDAQVKVWFQNRR------------------------------------MKWRHTRENLKSGQ 361
            .|....|:|||||.|                                    ::.||..|..::|.
Mouse  2637 GLKKRVVQVWFQNTRARERKGQFRAVGPAQSHKRCPFCRALFKAKSALESHIRSRHWNEGKQAGY 2701

  Fly   362 EKQPSAVPESGGVFKTSTPSGDGTPQEAL--DYSSDSCSSVDLSEQ 405
            ...||.:        .||..|..:||:.:  ||.|...:.:|||.:
Mouse  2702 SLPPSPL--------ISTEDGGESPQKYIYFDYPSLPLTKIDLSTE 2739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	15/91 (16%)
Zfhx4	NP_001355600.1	C2H2 Zn finger	613..634	CDD:275368
		C2H2 Zn finger	644..665	CDD:275368
		C2H2 Zn finger	699..716	CDD:275368
		C2H2 Zn finger	1396..1416	CDD:275371
		C2H2 Zn finger	1424..1441	CDD:275371
		SFP1	<1468..1608	CDD:227516
		C2H2 Zn finger	1540..1564	CDD:275368
		C2H2 Zn finger	1592..1610	CDD:275368
		COG5576	2098..2237	CDD:227863
		HOX	2127..2182	CDD:197696
		Homeobox	2226..2280	CDD:395001
		COG5576	2536..>2658	CDD:227863	36/147 (24%)
		Homeobox	2603..2656	CDD:395001	16/59 (27%)
		Homeobox	2926..2979	CDD:395001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910