DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and ESX1

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_703149.1	Gene:	ESX1 / 80712	HGNCID:	14865	Length:	406	Species:	Homo sapiens

Alignment Length:	230	Identity:	62/230 - (26%)
Similarity:	89/230 - (38%)	Gaps:	47/230 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 HTYPFVGLDKLFPGPYM----DYKSVLRPTPIRAAE-----HAAPTYPTLATNALLRFHQHQKQQ 195
            :|:..:|...|..|..:    |.|..:.....|..|     .:.|.|.|.|.|.:..........
Human     7 YTHSDIGYRSLAVGEDIEEVNDEKLTVTSLMARGGEDEENTRSKPEYGTEAENNVGTEGSVPSDD 71

  Fly   196 HQQHHHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTS 260
            ..:.....|.|:   ||.:.||...........||     |:|.|:|:    :.||..::
Human    72 QDREGGGGHEPE---QQQEEPPLTKPEQQQEEPPL-----LELKQEQE----EPPQTTVE----- 119

  Fly   261 PAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPD- 324
                          |.....|...|......:|||. .|..|:..|.:.||..|.:.:|   ||
Human   120 --------------GPQPAEGPQTAEGPQPPERKRR-RRTAFTQFQLQELENFFDESQY---PDV 166

  Fly   325 --RRKLAARLNLTDAQVKVWFQNRRMKWRHTRENL 357
              |.:||||||||:.:|:|||||||.||:..:..|
Human   167 VARERLAARLNLTEDRVQVWFQNRRAKWKRNQRVL 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	27/55 (49%)
ESX1	NP_703149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..142		27/140 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	138..143		3/5 (60%)
		Homeobox	142..195	CDD:278475	27/55 (49%)
		15 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-x	244..378
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910