Protein Alignment H2.0 and NANOG

DIOPT Version :10

• Sequence 1: NP_523488.2
• Gene: H2.0 / 33841
• FlyBaseID: FBgn0001170
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_079141.2
• Gene: NANOG / 79923
• HGNCID: 20857
• Length: 305
• Species: Homo sapiens
• Alignment Length: 188
• Identity: 51/188 - (27%)
• Similarity: 79/188 - (42%)
• Gaps: 56/188 - (29%)

  Fly   203 QHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAA 267
            :::|. |.......||..|     ::||.|...|                |:..:|.|      :
Human    33 ENYPS-LQMSSAEMPHTET-----VSPLPSSMDL----------------LIQDSPDS------S 69

  Fly   268 TSQNGAHGHGGGNGQGNASAGSNGKR------KRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRR 326
            ||..|.        |..::..|..|:      |:..:|.|||:.|...|..:||:|||::....:
Human    70 TSPKGK--------QPTSAEKSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQ 126

  Fly   327 KLAARLNLTDAQVKVWFQNRRMK---WRHTRENLKSGQEKQPSAVPESGGVFKTSTPS 381
            :|:..|||:..|||.||||:|||   |:      |:...|..:.|.:     |.|.|:
Human   127 ELSNILNLSYKQVKTWFQNQRMKSKRWQ------KNNWPKNSNGVTQ-----KASAPT 173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeodomain	292..352	CDD:459649	28/68 (41%)
NANOG	NP_079141.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		19/98 (19%)
		COG5576	74..191	CDD:227863	37/119 (31%)
		Homeodomain	97..152	CDD:459649	25/54 (46%)
		Required for DNA-binding. /evidence=ECO:0000269|PubMed:25825768	122..151		14/28 (50%)
		8 X repeats starting with a Trp in each unit	196..240
		Sufficient for transactivation activity. /evidence=ECO:0000250	196..240
		Sufficient for strong transactivation activity. /evidence=ECO:0000250	241..305