DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and NANOG

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_079141.2	Gene:	NANOG / 79923	HGNCID:	20857	Length:	305	Species:	Homo sapiens

Alignment Length:	188	Identity:	51/188 - (27%)
Similarity:	79/188 - (42%)	Gaps:	56/188 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 QHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAA 267
            :::|. |.......||..|     ::||.|...|                |:..:|.|      :
Human    33 ENYPS-LQMSSAEMPHTET-----VSPLPSSMDL----------------LIQDSPDS------S 69

  Fly   268 TSQNGAHGHGGGNGQGNASAGSNGKR------KRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRR 326
            ||..|.        |..::..|..|:      |:..:|.|||:.|...|..:||:|||::....:
Human    70 TSPKGK--------QPTSAEKSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQ 126

  Fly   327 KLAARLNLTDAQVKVWFQNRRMK---WRHTRENLKSGQEKQPSAVPESGGVFKTSTPS 381
            :|:..|||:..|||.||||:|||   |:      |:...|..:.|.:     |.|.|:
Human   127 ELSNILNLSYKQVKTWFQNQRMKSKRWQ------KNNWPKNSNGVTQ-----KASAPT 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	25/55 (45%)
NANOG	NP_079141.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		19/98 (19%)
		COG5576	74..191	CDD:227863	37/119 (31%)
		HOX	95..151	CDD:197696	25/55 (45%)
		Required for DNA-binding. /evidence=ECO:0000269\|PubMed:25825768	122..151		14/28 (50%)
		8 X repeats starting with a Trp in each unit	196..240
		Sufficient for transactivation activity. /evidence=ECO:0000250	196..240
		Sufficient for strong transactivation activity. /evidence=ECO:0000250	241..305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910