DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and ZFHX4

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_078997.4	Gene:	ZFHX4 / 79776	HGNCID:	30939	Length:	3616	Species:	Homo sapiens

Alignment Length:	462	Identity:	95/462 - (20%)
Similarity:	142/462 - (30%)	Gaps:	154/462 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MYGECEVN--PTLAKCPDPVNVDHELPTKESCASTTIVSTSPTSATSTTKVKLSFSVDRLLGSEP 84
            :|..|.|:  ...||     |......:..|..||.:: .||......|..|..:         |
Human  2360 VYKHCTVSGQTDAAK-----NAAAPAASSGSGTSTPLI-PSPKPEPEKTSPKPEY---------P 2409

  Fly    85 EESHRQSSSSPSTKSCCDGSILACCSF---------PHCFSQANAESRRFGHATLPP----TFTP 136
            .|..:||..||.::.......||..|.         |....|...:.:..|.   ||    |..|
Human  2410 AEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGR---PPSASQTPVP 2471

  Fly   137 TSSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQHQKQQHQQHHH 201
            :|........|....|...:.|:          .:.....:|||              :..|.|.
Human  2472 SSPLQISMTSLQNSLPPQLLQYQ----------CDQCTVAFPTL--------------ELWQEHQ 2512

  Fly   202 HQH---------HPKHLHQQHKPP-----PHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQ 252
            |.|         |...|.:....|     |:|......||.  .|||.:             |.|
Human  2513 HMHFLAAQNQFLHSPFLERPMDMPYMIFDPNNPLMTGQLLG--SSLTQM-------------PPQ 2562

  Fly   253 LLDIAPTSPAAAAAATSQ--------NGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKG 309
            ......|:|...||:..:        |.:...||.:|:..    ...||.|       :.:..:.
Human  2563 ASSSHTTAPTTVAASLKRKLDDKEDNNCSEKEGGNSGEDQ----HRDKRLR-------TTITPEQ 2616

  Fly   310 LEIQFQQQKYITKPDRRKL---AARLNLTDAQVKVWFQNRR------------------------ 347
            |||.:::....:.|.|:.|   |..:.|....|:|||||.|
Human  2617 LEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQFRAVGPAQSHKRCPFCR 2681

  Fly   348 ------------MKWRHTRENLKSGQEKQPSAVPESGGVFKTSTPSGDGTPQEAL--DYSSDSCS 398
                        ::.||..|..::|....||.:        .||..|..:||:.:  ||.|...:
Human  2682 ALFKAKSALESHIRSRHWNEGKQAGYSLPPSPL--------ISTEDGGESPQKYIYFDYPSLPLT 2738

  Fly   399 SVDLSEQ 405
            .:|||.:
Human  2739 KIDLSSE 2745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	15/91 (16%)
ZFHX4	NP_078997.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..611
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	646..667	CDD:275368
		C2H2 Zn finger	701..718	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1369
		C2H2 Zn finger	1399..1419	CDD:275371
		C2H2 Zn finger	1427..1444	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1474..1525
		C2H2 Zn finger	1543..1567	CDD:275368
		C2H2 Zn finger	1595..1613	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1806..1836
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1854..1903
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1993..2069
		COG5576	2101..2240	CDD:227863
		HOX	2130..2185	CDD:197696
		Homeobox	2229..2282	CDD:278475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2334..2356
		PHA02682	2350..>2506	CDD:177464	36/187 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2373..2476		27/120 (23%)
		COG5576	2542..>2664	CDD:227863	35/147 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2552..2609		16/75 (21%)
		Homeobox	2609..2661	CDD:278475	16/58 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2809..2856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2874..2930
		Homeobox	2933..2985	CDD:278475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3141..3221
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3330..3386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3492..3511
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3560..3583
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910