DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and Barhl2

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_075245.1	Gene:	Barhl2 / 65050	RGDID:	620726	Length:	384	Species:	Rattus norvegicus

Alignment Length:	291	Identity:	85/291 - (29%)
Similarity:	108/291 - (37%)	Gaps:	103/291 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 GLDKLFPG-----PYM--------------DYKSVLRPTPIRAAE--HAAPTYPTLATNALLRFH 189
            |:|.:..|     |.|              |::|...|:|....:  ..||:.|...|  |....
  Rat    13 GIDTILSGAGSGSPGMMNGDFRSLGEARTTDFRSQATPSPCSEIDTVGTAPSSPISVT--LEPPE 75

  Fly   190 QHQKQQHQQHHHHQHH----------PKHLHQ---QHKPPPHNSTTA----SALLAPLHSLTSLQ 237
            .|......|||||.||          |....|   |.:|||...:.|    ||..||..|.:|
  Rat    76 PHLVTDGPQHHHHLHHGQQPPPPSAPPAQSLQPSPQQQPPPQPQSAAQQLGSAAAAPRTSTSS-- 138

  Fly   238 LTQQQQRFLGKTPQQLLDI-APTSPAAAAAATSQ-------------NGAHG------------- 275
                   ||.|      || ..:.|.||.|..|.             |.||.
  Rat   139 -------FLIK------DILGDSKPLAACAPYSTSVSSPHHTPKQECNAAHESFRPKLEQEDSKT 190

  Fly   276 --------------HG---GGNGQGNASAGS---NGKRKRSWSRAVFSNLQRKGLEIQFQQQKYI 320
                          ||   .|:.:..:|..|   ..|:.|. :|..||:.|...||..|::|||:
  Rat   191 KLDKREDSQSDIKCHGTKEEGDREITSSRESPPVRAKKPRK-ARTAFSDHQLNQLERSFERQKYL 254

  Fly   321 TKPDRRKLAARLNLTDAQVKVWFQNRRMKWR 351
            :..||..|||.|||||.|||.|:||||.||:
  Rat   255 SVQDRMDLAAALNLTDTQVKTWYQNRRTKWK 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	29/52 (56%)
Barhl2	NP_075245.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		33/122 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..237		13/83 (16%)
		Homeobox	233..285	CDD:278475	29/51 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810