DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and ALX4

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_068745.2	Gene:	ALX4 / 60529	HGNCID:	450	Length:	411	Species:	Homo sapiens

Alignment Length:	288	Identity:	79/288 - (27%)
Similarity:	115/288 - (39%)	Gaps:	84/288 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 FPHCFSQANAESRRFGHATLPPTF--------TPTSSHTYPFVGLDKLFPGPYMDYKSVLRPTPI 167
            |...|..|.|:::.||.|.....:        ||..|........:|..|.|     |..:|.|
Human    43 FGTTFLSAAAKAQGFGDAKSRARYGAGQQDLATPLESGAGARGSFNKFQPQP-----STPQPQP- 101

  Fly   168 RAAEHAAPTYPTLATNALLRFHQHQKQQHQQHHHHQHHPKHLHQQH---KPPPHNSTT------- 222
                   |..|           |.|:||.|.....|   .||:.|.   |.||..|..
Human   102 -------PPQP-----------QPQQQQPQPQPPAQ---PHLYLQRGACKTPPDGSLKLQEGSSG 145

  Fly   223 -ASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHGGGNGQGNAS 286
             ::||..|.::         ::..||: |:...|.......::..:..:.|..|     .|..||
Human   146 HSAALQVPCYA---------KESSLGE-PELPPDSDTVGMDSSYLSVKEAGVKG-----PQDRAS 195

  Fly   287 A------------GSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPD---RRKLAARLNLTD 336
            :            .:.||::|  :|..|::.|.:.||..||:..|   ||   |.:||.|.:||:
Human   196 SDLPSPLEKADSESNKGKKRR--NRTTFTSYQLEELEKVFQKTHY---PDVYAREQLAMRTDLTE 255

  Fly   337 AQVKVWFQNRRMKWRHTRENLKSGQEKQ 364
            |:|:|||||||.||| .||  :.||.:|
Human   256 ARVQVWFQNRRAKWR-KRE--RFGQMQQ 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	26/55 (47%)
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..145		24/96 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..219		8/41 (20%)
		Homeobox	218..270	CDD:278475	26/54 (48%)
		OAR	387..404	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	391..404
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910