DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and Crx

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_068627.1	Gene:	Crx / 60446	RGDID:	620511	Length:	299	Species:	Rattus norvegicus

Alignment Length:	185	Identity:	49/185 - (26%)
Similarity:	71/185 - (38%)	Gaps:	61/185 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 PPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHGGG 279
            |.||.|..|.||..|     |:.|..|
  Rat     7 PGPHYSVNALALSGP-----SVDLMHQ-------------------------------------- 28

  Fly   280 NGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPD---RRKLAARLNLTDAQVKV 341
                 |...|:..||:...|..|:..|.:.||..|.:.:|   ||   |.::|.::||.:::|:|
  Rat    29 -----AVPYSSAPRKQRRERTTFTRSQLEELEALFAKTQY---PDVYAREEVALKINLPESRVQV 85

  Fly   342 WFQNRRMKWRHTRENLKSGQEKQPSAVPESGGVFKTSTPSGDGT-PQEALDYSSD 395
            ||:|||.|.|..|:..|  |::||..|.......|...    || |:.:.|..:|
  Rat    86 WFKNRRAKCRQQRQQQK--QQQQPPGVQAKARPAKRKA----GTSPRPSTDVCTD 134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	21/55 (38%)
Crx	NP_068627.1	Homeobox	43..93	CDD:278475	20/52 (38%)
Crx	NP_068627.1	TF_Otx	164..249	CDD:281521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910