DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and BARHL1

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_064448.1	Gene:	BARHL1 / 56751	HGNCID:	953	Length:	327	Species:	Homo sapiens

Alignment Length:	180	Identity:	50/180 - (27%)
Similarity:	70/180 - (38%)	Gaps:	58/180 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 HLH--QQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQ 270
            ||.  |...|....:.|:|.|:..:                      |.|..|.:..|..:::.|
Human    77 HLQPGQLSAPAQSRTVTSSFLIRDI----------------------LADCKPLAACAPYSSSGQ 119

  Fly   271 NGAHGHGG--------------GNGQGNASAGSNGK--------------------RKRSWSRAV 301
            ..|...||              .....|||:.|..|                    :|...:|..
Human   120 PAAPEPGGRLAAKAAEDFRDKLDKSGSNASSDSEYKVKEEGDREISSSRDSPPVRLKKPRKARTA 184

  Fly   302 FSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWR 351
            |::.|...||..|::|||::..||.:|||.|||||.|||.|:||||.||:
Human   185 FTDHQLAQLERSFERQKYLSVQDRMELAASLNLTDTQVKTWYQNRRTKWK 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	28/52 (54%)
BARHL1	NP_064448.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..184		12/71 (17%)
		Homeobox	182..235	CDD:395001	29/53 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810