DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and pitx2

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001017227.1	Gene:	pitx2 / 549981	XenbaseID:	XB-GENE-482492	Length:	345	Species:	Xenopus tropicalis

Alignment Length:	220	Identity:	70/220 - (31%)
Similarity:	106/220 - (48%)	Gaps:	25/220 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 HQHQKQQHQQHHHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQL 253
            |||..||||||.|  ||.:|.||||:.|...:.|          |.|:..:..|:....|...::
Frog    25 HQHHHQQHQQHQH--HHQQHHHQQHQQPQPQAVT----------LVSMASSLGQRSGECKARLEV 77

  Fly   254 LDIAPT-SPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQ 317
            ..|:.| ||.||....|      |...|...:....|..||:|. .|..|::.|.:.||..||:.
Frog    78 HTISDTSSPEAADKDKS------HQSKNEDSSTDDPSKKKRQRR-QRTHFTSQQLQELEATFQRN 135

  Fly   318 KYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTRENLKSGQEKQPSAVPESGGVFKTSTPSG 382
            :|.....|.::|...|||:|:|:|||:|||.||| .||..:..:..:....|:..|:.:   |..
Frog   136 RYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWR-KRERNQQAELCKNGFGPQFNGLMQ---PYD 196

  Fly   383 DGTPQEAL-DYSSDSCSSVDLSEQA 406
            |..|..:. ::::...:|..||.::
Frog   197 DMYPSYSYNNWAAKGLTSASLSTKS 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	22/52 (42%)
pitx2	NP_001017227.1	XRCC4	<84..144	CDD:284132	19/66 (29%)
		Homeobox	117..169	CDD:278475	22/51 (43%)
		OAR	303..320	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910