Protein Alignment H2.0 and PAX9

DIOPT Version :9

• Sequence 1: NP_523488.2
• Gene: H2.0 / 33841
• FlyBaseID: FBgn0001170
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_001359005.1
• Gene: PAX9 / 5083
• HGNCID: 8623
• Length: 341
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 54/240 - (22%)
• Similarity: 82/240 - (34%)
• Gaps: 73/240 - (30%)

  Fly    11 EQSMPENLSTHMYG-ECEVNPTLAKCPDPVNVDHELPTKESCASTTIVSTSPTSATSTTKVKLSF 74
            :.::|.|   |:|. ...:....||.|.|..|. .:|     .|..:..|.|:|.:.|..:.:..
Human   151 QPALPYN---HIYSYPSPITAAAAKVPTPPGVP-AIP-----GSVAMPRTWPSSHSVTDILGIRS 206

  Fly    75 SVDRLLGSEPEESHRQSSSSPSTKSCCDGSILACCSF----PHCFS----QANAESRRFGHATLP 131
            ..|::..|.|..       ||..:   :.|.|...:|    ||..:    .|..:..::|.|
Human   207 ITDQVSDSSPYH-------SPKVE---EWSSLGRNNFPAAAPHAVNGLEKGALEQEAKYGQA--- 258

  Fly   132 PTFTPTSSHTYPFVGLDKLFP-------GPYMDYKSVLRPTPIRAA---EHAAPTYPTLATN--- 183
            |...|...   .||....:.|       .|||.|.:.  |:...|.   :||..|  :|:.:
Human   259 PNGLPAVG---SFVSASSMAPYPTPAQVSPYMTYSAA--PSGYVAGHGWQHAGGT--SLSPHNCD 316

  Fly   184 --ALLRFHQHQKQQHQQHHHHQHHPKHLHQQHKPPPHNSTTASAL 226
              |.|.|...|..:...|                    |.|||||
Human   317 IPASLAFKGMQAAREGSH--------------------SVTASAL 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475
PAX9	NP_001359005.1	PAX	6..131	CDD:238076
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	7..63
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	82..130
		Interaction with KDM5B. /evidence=ECO:0000269|PubMed:12657635	168..189		7/26 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910