DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and PAX5

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_057953.1	Gene:	PAX5 / 5079	HGNCID:	8619	Length:	391	Species:	Homo sapiens

Alignment Length:	275	Identity:	52/275 - (18%)
Similarity:	90/275 - (32%)	Gaps:	67/275 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NPTLAKCPDPVNVDHELPTKESCASTTIVSTSPTSATSTTKVKLSFSVDRLLGSEPEESHRQSSS 93
            |||:...    .:...|..:..|.:.|:.|.|              |::|::.::.::...|...
Human   106 NPTMFAW----EIRDRLLAERVCDNDTVPSVS--------------SINRIIRTKVQQPPNQPVP 152

  Fly    94 SPSTKSCCDGSILACCSFPHCFSQANAESRRFGHATLPPTFTPTSSHTYPFVGLDKLFPGPYMDY 158
            :.|......||:          :|.::.|            |.::..:|...|:..: ..|..|.
Human   153 ASSHSIVSTGSV----------TQVSSVS------------TDSAGSSYSISGILGI-TSPSADT 194

  Fly   159 KSVLRPTPIRAAEHAAPTYPTLATNALLR-------FHQHQKQQHQQHHHHQHHPKHLHQQHKPP 216
            ....|...|:  |...|...:|.....||       |.|.|.:...:....||:...........
Human   195 NKRKRDEGIQ--ESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIK 257

  Fly   217 PHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAA---------AATSQNG 272
            |..:|..||:.:....|..:     :......||   .||..:.|...:         |:|:..|
Human   258 PEQTTEYSAMASLAGGLDDM-----KANLASPTP---ADIGSSVPGPQSYPIVTGRDLASTTLPG 314

  Fly   273 AHGHGGGNGQGNASA 287
            ...|....|||:.||
Human   315 YPPHVPPAGQGSYSA 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PAX	16..140	CDD:128645	10/51 (20%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		10/53 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..218		8/38 (21%)
		Pax2_C	279..389	CDD:403565	14/54 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910